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TREM-1, a negative regulator of human osteoclastogenesis

Title
TREM-1, a negative regulator of human osteoclastogenesis
Author
김태환
Keywords
TREM-1; OSTEOCLAST; RANK; M-CSF; Rheumatoid arthritis
Issue Date
2016-03
Publisher
ELSEVIER SCIENCE BV
Citation
IMMUNOLOGY LETTERS, v. 171, Page. 50-59
Abstract
Triggering receptor expressed on myeloid cells (TREMs) are a family of cell surface receptors that play important roles in innate and adaptive immunity. Among them, TREM-2 has been extensively studied for its role in osteoclast differentiation and its essential role in human osteoclastogenesis has been well established. However, much less has been discovered about the role of TREM-1 in human osteoclast differentiation. In this study, we investigate the role of TREM-1 in human osteoclast differentiation. Consistent with previous reports, TREM-2 expression was strongly increased during the generation of human osteoclast precursors. In contrast, TREM-1 expression was decreased during the generation of human osteoclast precursors. Stimulation of TREM-1 using agonistic anti-TREM-1 antibody resulted in suppression of RANKL-induced osteoclastogenesis, as evidenced by diminished formation of TRAP+ multinucleated cells. In addition, TREM-1 stimulation strongly suppressed RANKL-induced expression of osteoclast-related genes such as cathepsin K and NFATc1. TREM-1 stimulation also down-regulated gene expression and cell surface expression of M-CSF receptor that is essential for osteoclast differentiation and survival. In synovial fluid macrophages of rheumatoid arthritis (RA) patients, TREM-1 stimulation suppressed osteoclastogenesis. In conclusion, we demonstrate that TREM-1 acts as a negative regulator of human osteoclast differentiation and identify a novel mechanism of negative regulation of osteoclastogenesis that plays a role in inflammation. (C) 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0165247816300116?via%3Dihubhttp://hdl.handle.net/20.500.11754/39758
ISSN
0165-2478; 1879-0542
DOI
10.1016/j.imlet.2016.02.002
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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