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dc.contributor.author최한곤-
dc.date.accessioned2018-02-22T05:12:00Z-
dc.date.available2018-02-22T05:12:00Z-
dc.date.issued2015-11-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 495, No. 1, Page. 67-74en_US
dc.identifier.issn0378-5173-
dc.identifier.issn1873-3476-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517315301794-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/39592-
dc.description.abstractTo develop a novel sodium fusidate-loaded film-forming hydrogel (FFH) for easy application and excellent wound healing, various FFH formulations and corresponding FFH dried films were prepared with drug, polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), propylene glycol, ethanol and water, and their film forming times, mechanical properties, drug release, in vivo wound healing in rat and histopathology were assessed. The sodium fusidate-loaded FFH composed of sodium fusidate/PVP/PVA/propylene glycol/ethanol/water at the weight ratio of 1/2/12/3/8/74 could form a corresponding dried film in the wound sites promptly due to fast film-forming time of about 4 min. This FFH showed an appropriate hardness and adhesiveness. Furthermore, this corresponding dried film provided an excellent flexibility and elasticity, and gave relatively high drug release. As compared with the sodium fusidate-loaded commercial product, it significantly improved excision and infection wound healing in rats. This FFH was stable at 45 degrees C for at least 6 months. Therefore, this novel sodium fusidate-loaded FFH would be an effective pharmaceutical product with easy application for the treatment of wounds. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of South Korea (NRF) grant funded by the South Korea government (MEST) (No. 2015R1A2A2A05027872).en_US
dc.language.isoen_USen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.subjectSodium fusidateen_US
dc.subjectFilm-forming hydrogelen_US
dc.subjectFilm-forming timeen_US
dc.subjectPolyvinylalcoholen_US
dc.subjectPolyvinylpyrrolidoneen_US
dc.subjectWound healingen_US
dc.subjectHistological examinationen_US
dc.subjectDRUG-DELIVERY SYSTEMen_US
dc.subjectPOLYVINYL-ALCOHOLen_US
dc.subjectGEL CHARACTERIZATIONen_US
dc.subjectACIDen_US
dc.subjectALGINATEen_US
dc.subjectCHITOSANen_US
dc.subjectRELEASEen_US
dc.subjectCARBOXYMETHYLCELLULOSEen_US
dc.subjectINFECTIONSen_US
dc.subjectNANOFIBERSen_US
dc.titleNovel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healingen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume495-
dc.identifier.doi10.1016/j.ijpharm.2015.08.082-
dc.relation.page67-74-
dc.relation.journalINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.contributor.googleauthorKim, Dong Wuk-
dc.contributor.googleauthorKim, Kyung Soo-
dc.contributor.googleauthorSeo, Youn Gee-
dc.contributor.googleauthorLee, Beom-Jin-
dc.contributor.googleauthorPark, Young Joon-
dc.contributor.googleauthorYoun, Yu Seok-
dc.contributor.googleauthorKim, Jong Oh-
dc.contributor.googleauthorYong, Chul Soon-
dc.contributor.googleauthorJin, Sung Giu-
dc.contributor.googleauthorChoi, Han Gon-
dc.relation.code2015002419-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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