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Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing

Title
Novel sodium fusidate-loaded film-forming hydrogel with easy application and excellent wound healing
Author
최한곤
Keywords
Sodium fusidate; Film-forming hydrogel; Film-forming time; Polyvinylalcohol; Polyvinylpyrrolidone; Wound healing; Histological examination; DRUG-DELIVERY SYSTEM; POLYVINYL-ALCOHOL; GEL CHARACTERIZATION; ACID; ALGINATE; CHITOSAN; RELEASE; CARBOXYMETHYLCELLULOSE; INFECTIONS; NANOFIBERS
Issue Date
2015-11
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF PHARMACEUTICS, v. 495, No. 1, Page. 67-74
Abstract
To develop a novel sodium fusidate-loaded film-forming hydrogel (FFH) for easy application and excellent wound healing, various FFH formulations and corresponding FFH dried films were prepared with drug, polyvinylalcohol (PVA), polyvinylpyrrolidone (PVP), propylene glycol, ethanol and water, and their film forming times, mechanical properties, drug release, in vivo wound healing in rat and histopathology were assessed. The sodium fusidate-loaded FFH composed of sodium fusidate/PVP/PVA/propylene glycol/ethanol/water at the weight ratio of 1/2/12/3/8/74 could form a corresponding dried film in the wound sites promptly due to fast film-forming time of about 4 min. This FFH showed an appropriate hardness and adhesiveness. Furthermore, this corresponding dried film provided an excellent flexibility and elasticity, and gave relatively high drug release. As compared with the sodium fusidate-loaded commercial product, it significantly improved excision and infection wound healing in rats. This FFH was stable at 45 degrees C for at least 6 months. Therefore, this novel sodium fusidate-loaded FFH would be an effective pharmaceutical product with easy application for the treatment of wounds. (C) 2015 Elsevier B.V. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0378517315301794http://hdl.handle.net/20.500.11754/39592
ISSN
0378-5173; 1873-3476
DOI
10.1016/j.ijpharm.2015.08.082
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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