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Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway

Title
Brassinosteroid regulates stomatal development by GSK3-mediated inhibition of a MAPK pathway
Author
김태욱
Keywords
RECEPTOR KINASE BRI1; SIGNAL-TRANSDUCTION; TRANSCRIPTION FACTORS; GSK3-LIKE KINASES; PLANT-GROWTH; ARABIDOPSIS; BZR1; DIFFERENTIATION; INTEGRATION; PERCEPTION
Issue Date
2012-02
Publisher
Nature Publishing Group
Citation
Nature, 2012, 482(7385), P.419-441
Abstract
Plants must coordinate the regulation of biochemistry and anatomy to optimize photosynthesis and water-use efficiency. The formation of stomata, epidermal pores that facilitate gas exchange, is highly coordinated with other aspects of photosynthetic development. The signalling pathways controlling stomata development are not fully understood(1,2), although mitogen-activated protein kinase (MAPK) signalling is known to have key roles. Here we demonstrate in Arabidopsis that brassinosteroid regulates stomatal development by activating the MAPK kinase kinase (MAPKKK) YDA (also known as YODA). Genetic analyses indicate that receptor kinase-mediated brassinosteroid signalling inhibits stomatal development through the glycogen synthase kinase 3 (GSK3)-like kinase BIN2, and BIN2 acts upstream of YDA but downstream of the ERECTA family of receptor kinases. Complementary in vitro and in vivo assays show that BIN2 phosphorylates YDA to inhibit YDA phosphorylation of its substrate MKK4, and that activities of downstream MAPKs are reduced in brassinosteroid-deficient mutants but increased by treatment with either brassinosteroid or GSK3-kinase inhibitor. Our results indicate that brassinosteroid inhibits stomatal development by alleviating GSK3-mediated inhibition of this MAPK module, providing two key links; that of a plant MAPKKK to its upstream regulators and of brassinosteroid to a specific developmental output.
URI
https://www.nature.com/articles/nature10794
ISSN
0028-0836; 1476-4687
DOI
10.1038/nature10794
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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