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Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital

Title
Epidemiology and Clinical Characteristics of Clostridium difficile Infection in a Korean Tertiary Hospital
Author
김지은
Keywords
Clostridium difficile Infection; Incidence; Clinical Characteristics; Toxin Type
Issue Date
2011-10
Publisher
Korean ACDC Medical Science
Citation
Journal of Korean Medical Science, 2011, 26(10), P.1258-1264
Abstract
In order to investigate the incidence, clinical and microbiologic characteristics of Clostridium difficile infection (CDI) in Korea, a prospective observational study was performed. From September 2008 through January 2010, all patients whose stool was tested for toxin assay A&B and/or C. difficile culture were studied for clinical characteristics. Toxin types of the isolates from stool were tested. The mean incidence of CDI per 100,000 patient-days was 71.6 by month (range, 52.5-114.0), and the ratio of CDI to antibiotic-associated diarrhea was 0.23. Among 200 CDI patients, 37.5% (75/200) was severe CDI based on severity score. Clinical outcome of 189 CDI was as followed; 25.9% (49/189) improved without treatment, 84.3% (118/140) achieved clinical cure and attributed mortality was 0.7% (1/140) with the treatment. Recurrence rate was 21.4% (30/140) and cure without recurrence was 66.4% (93/140). The most common type of toxin was toxin A-positive/toxin B-positive strain (77.5%), toxin A-negative/toxin B-positive strains or binary toxin-producing strains comprised 15.4% or 7.1%, respectively. In conclusion, the incidence of CDI in Korea is a little higher than other reports during the non-epidemic setting. We expect that the change of epidemiology and clinical severity in CDI can be evaluated based on these results.
URI
https://synapse.koreamed.org/DOIx.php?id=10.3346/jkms.2011.26.10.1258
ISSN
1011-8934
DOI
10.3346/jkms.2011.26.10.1258
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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