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dc.contributor.author김영미-
dc.date.accessioned2018-02-19T01:59:47Z-
dc.date.available2018-02-19T01:59:47Z-
dc.date.issued2015-08-
dc.identifier.citationBIOCHEMICAL PHARMACOLOGY, v. 96, No. 3, Page. 256-266en_US
dc.identifier.issn0006-2952-
dc.identifier.issn1873-2968-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S000629521500297X-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/38035-
dc.description.abstractThe present study was aimed to investigate the metabolomics of sulfur amino acids in Zucker diabetic fatty (ZDF) rats, an obese type 2 diabetic animal model. Plasma levels of total cysteine, homocysteine and methionine, but not glutathione (GSH) were markedly decreased in ZDF rats. Hepatic methionine, homocysteine, cysteine, betaine, taurine, spermidine and spermine were also decreased. There are no significant difference in hepatic S-adenosylmethionine, S-adenosylhomocysteine, GSH, GSH disulfide, hypotaurine and putrescine between control and ZDF rats. Hepatic SAH hydrolase, betaine-homocysteine methyltransferase and methylene tetrahydrofolate reductase were up-regulated while activities of gamma-glutamylcysteine ligase and methionine synthase were decreased. The area under the curve (AUC) of methionine and methionine-d(4) was not significantly different in control and ZDF rats treated with a mixture of methionine (60 mg/kg) and methionine-d(4) (20 mg/kg). Moreover, the AUC of the increase in plasma total homocysteine was comparable between two groups, although the homocysteine concentration curve was shifted leftward in ZDF rats, suggesting that the plasma total homocysteine after the methionine loading was rapidly increased and normalized in ZDF rats. These results show that the AUC of plasma homocysteine is not responsive to the up-regulation of hepatic BHMT in ZDF rats. The present study suggests that the decrease in hepatic methionine may be responsible for the decreases in its metabolites, such as homocysteine, cysteine, and taurine in liver and consequently decreased plasma homocysteine levels. (C) 2015 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipThis work was supported by the Priority Research Centers Program (2009-0093815) through the Research Foundation of Korea (NRF) grant, funded by the Korean Government (MEST).en_US
dc.language.isoen_USen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.subjectZDF raten_US
dc.subjectSulfur amino acidsen_US
dc.subjectType 2 diabetesen_US
dc.subjectPERFORMANCE LIQUID-CHROMATOGRAPHYen_US
dc.subjectPLASMA HOMOCYSTEINE ELEVATIONen_US
dc.subjectMETHIONINE LOADING TESTen_US
dc.subjectADENOSYL-L-METHIONINEen_US
dc.subjectHEPATIC-METABOLISMen_US
dc.subjectCYSTEINE DIOXYGENASEen_US
dc.subjectMETHYL-GROUP; BETAINEen_US
dc.subjectLIVERen_US
dc.subjectMICEen_US
dc.titleSulfur amino acid metabolism in Zucker diabetic fatty ratsen_US
dc.typeArticleen_US
dc.relation.no3-
dc.relation.volume96-
dc.identifier.doi10.1016/j.bcp.2015.05.014-
dc.relation.page256-266-
dc.relation.journalBIOCHEMICAL PHARMACOLOGY-
dc.contributor.googleauthorKwak, HC-
dc.contributor.googleauthorKim, YM-
dc.contributor.googleauthorOh, SJ-
dc.contributor.googleauthorKim, SK-
dc.relation.code2015000537-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidymikim12-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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