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Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri

Title
Species-wide whole genome sequencing reveals historical global spread and recent local persistence in Shigella flexneri
Author
김동욱
Keywords
O-ANTIGEN MODIFICATION; ESCHERICHIA-COLI; SALMONELLA-TYPHIMURIUM; PATHOGENICITY ISLAND; ENTERIC MULTICENTER; VACCINE DEVELOPMENT; ASIAN COUNTRIES; YOUNG-CHILDREN; BAPS SOFTWARE; IN-VITRO
Issue Date
2015-08
Publisher
ELIFE SCIENCES PUBLICATIONS LTD
Citation
ELIFE, v. 4, Article ID. e7335
Abstract
Shigella flexneri is the most common cause of bacterial dysentery in low-income countries. Despite this, S. flexneri remains largely unexplored from a genomic standpoint and is still described using a vocabulary based on serotyping reactions developed over half-a-century ago. Here we combine whole genome sequencing with geographical and temporal data to examine the natural history of the species. Our analysis subdivides S. flexneri into seven phylogenetic groups (PGs); each containing two-or-more serotypes and characterised by distinct virulence gene complement and geographic range. Within the S. flexneri PGs we identify geographically restricted sub-lineages that appear to have persistently colonised regions for many decades to over 100 years. Although we found abundant evidence of antimicrobial resistance (AMR) determinant acquisition, our dataset shows no evidence of subsequent intercontinental spread of antimicrobial resistant strains. The pattern of colonisation and AMR gene acquisition suggest that S. flexneri has a distinct life-cycle involving local persistence. DOI: 10.7554/eLife.07335.001
URI
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4522646/http://hdl.handle.net/20.500.11754/37960
ISSN
2050-084X
DOI
10.7554/eLife.07335
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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