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Different therapeutic responses in chronic obstructive pulmonary disease subgroups

Title
Different therapeutic responses in chronic obstructive pulmonary disease subgroups
Author
김태형
Keywords
COPD; diffusing capacity; emphysema; lung volume
Issue Date
2011-08
Publisher
INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D), 68 BOULEVARD SAINT-MICHEL,, 75006 PARIS, FRANCE
Citation
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 권: 15, 호: 8, 페이지: 1104-1110
Abstract
SETTING: Eleven referring hospitals in South Korea. OBJECTIVE: To compare therapeutic responses in chronic obstructive pulmonary disease (COPD) subgroups, classified by diffusing capacity of the lung for carbon monoxide (DL(CO)) and lung volume. DESIGN: A total of 130 stable male COPD patients were classified into four subgroups according to baseline DL(CO) and residual volume/total lung capacity (RV/TLC) ratio. We compared therapeutic responses to short acting beta(2)-agonist (SABA) and 3-month combined inhalation of long-acting beta(2)-agonist (LABA) and corticosteroid among patients with these subgroups. RESULTS: Among the 130 COPD patients, 41 (31.5%) had normal DL(CO) and RV/TLC, 28 (21.5%) low DL(CO) and normal RV/TLC, 31 (23.8%) normal DL(CO) and high RV/TLC, and 30 (23.1%) low DL(CO) and high RV/TLC. The normal DL(CO)/high RV/TLC subgroup showed a significantly larger flow response (changes in forced expiratory volume in 1 s) to salbutamol than the normal DL(CO)/RV/TLC subgroups, and a larger volume response (changes in forced vital capacity) than the two normal RV/TLC subgroups. The normal DL(CO)/high RV/TLC subgroup also showed significantly larger flow and volume response to 3-month combined inhalation of LABA and corticosteroid than the two normal RV/TLC subgroups. CONCLUSION: COPD subgroups classified by DLco and RV/TLC may have different pulmonary function responses to pharmacological treatment.
URI
http://www.ingentaconnect.com/content/iuatld/ijtld/2011/00000015/00000008/art00017
ISSN
1027-3719
DOI
10.5588/ijtld.10.0553
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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