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Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players

Title
Influences of the G2350A polymorphism in the ACE Gene on cardiac structure and function of ball game players
Author
김성민
Issue Date
2012-01
Publisher
BioMed Central, 2012.
Citation
Journal of Negative Results in Biomedicine, Vol 11, Iss 1, p 6 (2012)
Abstract
BackgroundExcept for the I/D polymorphism in the angiotensin I-converting enzyme (ACE) gene, there were few reports about the relationship between other genetic polymorphisms in this gene and the changes in cardiac structure and function of athletes. Thus, we investigated whether the G2350A polymorphism in the ACE gene is associated with the changes in cardiac structure and function of ball game players. Total 85 healthy ball game players were recruited in this study, and they were composed of 35 controls and 50 ball game players, respectively. Cardiac structure and function were measured by 2-D echocardiography, and the G2350A polymorphism in the ACE gene analyzed by the SNaPshot method.ResultsThere were significant differences in left ventricular mass index (LVmassI) value among each sporting discipline studied. Especially in the athletes of basketball disciplines, indicated the highest LVmassI value than those of other sporting disciplines studied (p < 0.05). However, there were no significant association between any echocardiographic data and the G2350A polymorphism in the ACE gene in the both controls and ball game players.ConclusionsOur data suggests that the G2350A polymorphism in the ACE gene may not significantly contribute to the changes in cardiac structure and function of ball game players, although sporting disciplines of ball game players may influence the changes in LVmassI value of these athletes. Further studies using a larger sample size and other genetic markers in the ACE gene will be needed.Document Typearticle
URI
http://search.proquest.comdocview/921150505?accountid=11283http://hdl.handle.net/20.500.11754/37533
ISSN
1477-5751
DOI
10.1186/1477-5751-11-6
Appears in Collections:
COLLEGE OF ART AND PHYSICAL EDUCATION[S](예술·체육대학) > PHYSICAL EDUCATION(체육학과) > Articles
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