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dc.contributor.author배상철-
dc.date.accessioned2018-02-14T07:17:46Z-
dc.date.available2018-02-14T07:17:46Z-
dc.date.issued2012-01-
dc.identifier.citationRHEUMATOLOGY INTERNATIONAL, 권: 32, 호: 1, 페이지: 91-96en_US
dc.identifier.issn0172-8172-
dc.identifier.urihttp://search.proquest.com/docview/914486293?accountid=11283-
dc.identifier.urihttps://link.springer.com/article/10.1007%2Fs00296-010-1589-9-
dc.description.abstractSeveral studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP-1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF > 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR-1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP-1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04), and one haplotype (ht6, OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype (ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10-0.63, P = 0.003; P (corr) = 0.02). Despite a possible association between PARP-1 and the radiological severity of RA, this study found no statistical association between PARP-1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population.en_US
dc.description.sponsorshipThis study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010252).en_US
dc.language.isoenen_US
dc.publisherSPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANYen_US
dc.subjectRheumatoid arthritis (RA)en_US
dc.subjectPoly(ADP-ribose) polymerase (PARP)en_US
dc.subjectPolymorphismen_US
dc.subjectSusceptibilityen_US
dc.titleLack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean populationen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume32-
dc.identifier.doi10.1007/s00296-010-1589-9-
dc.relation.page91-96-
dc.relation.journalRHEUMATOLOGY INTERNATIONAL-
dc.contributor.googleauthorLee, Kyeong-A-
dc.contributor.googleauthorBang, So-Young-
dc.contributor.googleauthorPark, Byung-Lae-
dc.contributor.googleauthorKim, Jeong-Hyun-
dc.contributor.googleauthorShin, Hyoung-Doo-
dc.contributor.googleauthorBae, Sang-Cheol-
dc.relation.code2012230754-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidscbae-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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