Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 배상철 | - |
dc.date.accessioned | 2018-02-14T07:17:46Z | - |
dc.date.available | 2018-02-14T07:17:46Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | RHEUMATOLOGY INTERNATIONAL, 권: 32, 호: 1, 페이지: 91-96 | en_US |
dc.identifier.issn | 0172-8172 | - |
dc.identifier.uri | http://search.proquest.com/docview/914486293?accountid=11283 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007%2Fs00296-010-1589-9 | - |
dc.description.abstract | Several studies have investigated the roles of genetic polymorphisms in rheumatoid arthritis (RA). Some of these studies reported that polymorphisms of poly(ADP-ribose) polymerase 1 gene (PARP-1) are linked to rheumatoid arthritis. Poly(ADP-ribose) polymerase is an enzyme involved in DNA repair, genomic stability, apoptosis, gene transcription, proliferation, and autoimmunity. To determine whether genetic polymorphisms of PARP-1 are related to rheumatoid arthritis in a Korean population, six single nucleotide polymorphisms (SNPs), which were selected based on LDs and minor allele frequency (MAF > 0.05) in our previous study, were genotyped in 1,202 patients with rheumatoid arthritis and 979 unrelated healthy controls. As a result, no significant association between the susceptibility to rheumatoid arthritis and PAPR-1 polymorphisms was found. However, in further analysis depending on the radiological severity of rheumatoid arthritis, one PARP-1 polymorphism, rs1805413 (OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04), and one haplotype (ht6, OR = 0.11; 95% CI = 0.02-0.55; P = 0.007; P (corr) = 0.04) were significantly associated with the radiological severity risk of RA in a recessive model. In addition, a recessive model revealed a correlation between one RA haplotype (ht4) and anti-CCP antibody negativity (OR 0.24, 95% CI 0.10-0.63, P = 0.003; P (corr) = 0.02). Despite a possible association between PARP-1 and the radiological severity of RA, this study found no statistical association between PARP-1 polymorphisms and the susceptibility to rheumatoid arthritis in a Korean population. | en_US |
dc.description.sponsorship | This study was supported by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare and Family Affairs, Republic of Korea (A010252). | en_US |
dc.language.iso | en | en_US |
dc.publisher | SPRINGER HEIDELBERG, TIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANY | en_US |
dc.subject | Rheumatoid arthritis (RA) | en_US |
dc.subject | Poly(ADP-ribose) polymerase (PARP) | en_US |
dc.subject | Polymorphism | en_US |
dc.subject | Susceptibility | en_US |
dc.title | Lack of association between Poly(ADP-ribose) polymerase (PARP) polymorphisms and rheumatoid arthritis in a Korean population | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 32 | - |
dc.identifier.doi | 10.1007/s00296-010-1589-9 | - |
dc.relation.page | 91-96 | - |
dc.relation.journal | RHEUMATOLOGY INTERNATIONAL | - |
dc.contributor.googleauthor | Lee, Kyeong-A | - |
dc.contributor.googleauthor | Bang, So-Young | - |
dc.contributor.googleauthor | Park, Byung-Lae | - |
dc.contributor.googleauthor | Kim, Jeong-Hyun | - |
dc.contributor.googleauthor | Shin, Hyoung-Doo | - |
dc.contributor.googleauthor | Bae, Sang-Cheol | - |
dc.relation.code | 2012230754 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | scbae | - |
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