Glia/ischemia tissue dual specific gene expression vector for glioblastoma gene therapy
- Title
- Glia/ischemia tissue dual specific gene expression vector for glioblastoma gene therapy
- Other Titles
- ischemia tissue dual specific gene expression vector for glioblastoma gene therapy
- Author
- 이민형
- Keywords
- Gene regulation; Hypoxia; Glioblastoma; Gene therapy
- Issue Date
- 2011-11
- Publisher
- Elsevier B.V.
- Citation
- Journal of Controlled Release. Nov 2011, 152 Suppl 1: P.146-148
- Abstract
- SUMMARY: For glia/hypoxia dual specific gene expression, a dual specific expression vector was developed. pEpo-NI2-SV-Luc or pEpo-NI2-SV-was constructed with the nestin intron 2 (NI2)-SV40 promoter and erythropoietin (Epo) enhancer for glia cell and hypoxia specific gene expression. Gene expression by pEpo-NI2-SV-Luc was higher than pSV-Luc in glioblastoma cells under hypoxia. pEpo-NI2-SV-TK was constructed and transfected into C6 cells. The growth of the pEpo-NI2-SV-TK transfected cells was significantly suppressed in the presence of GCV.
- URI
- http://www.sciencedirect.com/science/article/pii/S0168365911006675?via%3Dihubhttp://hdl.handle.net/20.500.11754/37445
- ISSN
- 0168-3659
- DOI
- 10.1016/j.jconrel.2011.08.053
- Appears in Collections:
- COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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