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Glia/ischemia tissue dual specific gene expression vector for glioblastoma gene therapy

Title
Glia/ischemia tissue dual specific gene expression vector for glioblastoma gene therapy
Other Titles
ischemia tissue dual specific gene expression vector for glioblastoma gene therapy
Author
이민형
Keywords
Gene regulation; Hypoxia; Glioblastoma; Gene therapy
Issue Date
2011-11
Publisher
Elsevier B.V.
Citation
Journal of Controlled Release. Nov 2011, 152 Suppl 1: P.146-148
Abstract
SUMMARY: For glia/hypoxia dual specific gene expression, a dual specific expression vector was developed. pEpo-NI2-SV-Luc or pEpo-NI2-SV-was constructed with the nestin intron 2 (NI2)-SV40 promoter and erythropoietin (Epo) enhancer for glia cell and hypoxia specific gene expression. Gene expression by pEpo-NI2-SV-Luc was higher than pSV-Luc in glioblastoma cells under hypoxia. pEpo-NI2-SV-TK was constructed and transfected into C6 cells. The growth of the pEpo-NI2-SV-TK transfected cells was significantly suppressed in the presence of GCV.
URI
http://www.sciencedirect.com/science/article/pii/S0168365911006675?via%3Dihubhttp://hdl.handle.net/20.500.11754/37445
ISSN
0168-3659
DOI
10.1016/j.jconrel.2011.08.053
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > BIOENGINEERING(생명공학과) > Articles
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