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Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis

Title
Flt3 Signaling-Dependent Dendritic Cells Protect against Atherosclerosis
Author
최재훈
Keywords
Animals; Antigens; CD; metabolism; Aorta; drug effects; immunology; Atherosclerosis; genetics; pathology; Dendritic Cells; Gene Expression Regulation; Leukocyte Reduction Procedures; Macrophage Colony-Stimulating Factor; Macrophages; Membrane Proteins; pharmacology; Mice; Inbred BALB C; Inbred C57BL; Knockout; Monocytes; Signal Transduction; fms-Like Tyrosine Kinase 3
Issue Date
2011-11
Publisher
Elsevier Inc.
Citation
Immunity v.35 no.5, 2011, P819 - 831
Abstract
Early events in atherosclerosis occur in the aortic intima and involve monocytes that become macrophages. We looked for these cells in the steady state adult mouse aorta, and surprisingly, we found a dominance of dendritic cells (DCs) in the intima. In contrast to aortic adventitial macrophages, CD11c(+)MHC II(hi) DCs were poorly phagocytic but were immune stimulatory. DCs were of two types primarily: classical Flt3-Flt3L signaling-dependent, CD103(+)CD11b(-) DCs and macrophage-colony stimulating factor (M-CSF)-dependent, CD14(+)CD11b(+)DC-SIGN(+) monocyte-derived DCs. Both types expanded during atherosclerosis. By crossing Flt3(-/-) to Ldlr(-/-) atherosclerosis-prone mice, we developed a selective and marked deficiency of classical CD103(+) aortic DCs, and they were associated with exacerbated atherosclerosis without alterations in blood lipids. Concomitantly, the Flt3(-/-) Ldlr(-/-) mice had fewer Foxp3(+) Treg cells and increased inflammatory cytokine mRNAs in the aorta. Therefore, functional DCs are dominant in normal aortic intima and, in contrast to macrophages, CD103(+) classical DCs are associated with atherosclerosis protection.
URI
http://www.sciencedirect.com/science/article/pii/S1074761311004560?via%3Dihubhttp://www.cell.com/immunity/fulltext/S1074-7613(11)00456-0
ISSN
1097-4180
DOI
10.1016/j.immuni.2011.09.014
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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