The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model

Title
The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model
Author
최호순
Keywords
DA-6034; Intestinal permeability; Small intestinal injury model; Leaky gut syndrome
Issue Date
2016-03
Publisher
EDITORIAL OFFICE GUT & LIVER
Citation
GUT AND LIVER, v. 10, NO 3, Page. 406-411
Abstract
Background/Aims: DA-6034 has anti-inflammatory activities and exhibits cytoprotective effects in acute gastric injury models. However, explanations for the protective effects of DA-6034 on intestinal permeability are limited. This study sought to investigate the effect of DA-6034 on intestinal permeability in an indomethacin-induced small intestinal injury model and its protective effect against small intestinal injury. Methods: Rats in the treatment group received DA-6034 from days 0 to 2 and indomethacin from days 1 to 2. Rats in the control group received indomethacin from days 1 to 2. On the fourth day, the small intestines were examined to compare the severity of inflammation. Intestinal permeability was evaluated by using fluorescein isothiocyanate-labeled dextran. Western blotting was performed to confirm the association between DA-6034 and the extracellular signal-regulated kinase (ERK) pathway. Results: The inflammation scores in the treatment group were lower than those in the control group, but the difference was statistically insignificant. Hemorrhagic lesions in the treatment group were broader than those in the control group, but the difference was statistically insignificant. Intestinal permeability was lower in the treatment group than in the control group. DA-6034 enhanced extracellular signal-regulated kinase expression, and intestinal permeability was negatively correlated with ERK expression. Conclusions: DA-6034 may decrease intestinal permeability in an indomethacin-induced intestinal injury model via the ERK pathway.
URI
http://www.gutnliver.org/journal/view.html?doi=10.5009/gnl15251http://hdl.handle.net/20.500.11754/37172
ISSN
1976-2283; 2005-1212
DOI
10.5009/gnl15251
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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