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Smad4 May Help to Identify a Subset of Colorectal Cancer Patients with Early Recurrence after Curative Therapy

Title
Smad4 May Help to Identify a Subset of Colorectal Cancer Patients with Early Recurrence after Curative Therapy
Author
백승삼
Keywords
Smad4; Colorectal cancer; Carcinogenesis; Prognosis
Issue Date
2011-10
Publisher
H G E UPDATE MEDICAL PUBLISHING S A, PO BOX 17257, ATHENS GR-10024, GREECE
Citation
HEPATO-GASTROENTEROLOGY; NOV-DEC 2011, 58 112, p1933-p1936
Abstract
Background/Aims: Loss of Smad4 function is associated with the acquisition of advanced colorectal cancer phenotypes. We investigated the role of Smad4 as a prognostic marker after curative therapy. Methodology: Four hundred and twenty nine consecutive colorectal cancers were analyzed by tissue microarray-based immunohistochemical assay. Results: Smad4 protein was expressed in 61.5% (24/39), 53.1% (77/145), 41.3% (78/189) and 34.8% (16/46) of stage I, II, III and IV cancers, respectively. Lymphovascular invasion and lymph node metastasis were strongly correlated with the loss of Smad4 expression (p<0.0001 and p=0.002, respectively). Disease-free survival did not differ between Smad4-positive and Smad4-negative cancers. In stage Ill disease, time to recurrence after curative therapy was shorter in the Smad4-negative than in the Smad4-positive cancers (20.1 +/- 15.1 vs. 34.6 +/- 34.1 months, p=0.035). Conclusions: Smad4 protein is of no value in predicting recurrence after curative therapy in colorectal cancer, but it may be helpful in identifying a subset of patients with early recurrence after curative therapy.
URI
http://europepmc.org/abstract/med/22024061
ISSN
0172-6390
DOI
10.5754/hge11186
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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