Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-02-13T04:12:06Z | - |
dc.date.available | 2018-02-13T04:12:06Z | - |
dc.date.issued | 2012-01 | - |
dc.identifier.citation | ANTI-CANCER DRUGS, 권: 23, 호: 1, 페이지: 43-50 | en_US |
dc.identifier.issn | 0959-4973 | - |
dc.identifier.uri | https://insights.ovid.com/crossref?an=00001813-201201000-00005 | - |
dc.description.abstract | Radiation resistance can be overcome by a combination treatment with chemical modifiers. Here, we showed that treatment with 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one (BHP), a new 2-pyrone derivative, in combination with ionizing radiation enhances the sensitivity of human cervical cancer cells to ionizing radiation through overproduction of reactive oxygen species (ROS). The combined treatment with BHP and ionizing radiation caused a decrease in clonogenic survival and an increase in apoptotic cell death in cervical cancer cells. The combined treatment promoted conformational activation of Bax and led to mitochondrial apoptotic cell death. The combination treatment also induced a marked increase in intracellular ROS level. Inhibition of ROS attenuated the radiosensitizing effect of BHP, concurrent with a decrease in Bax activation, a decrease in mitochondrial cell death, and an increase in clonogenic survival. These results indicate that BHP synergistically enhances sensitivity of human cervical cancer cells to ionizing radiation through elevation of intracellular ROS and that ROS-dependent Bax activation is critically involved in the increase in apoptotic cell death induced by the combined treatment with BHP and ionizing radiation. Anti-Cancer Drugs 23:43-50 (C) 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins. | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation and the Ministry of Education, Science and Technology, Korean government, through its National Nuclear Technology Program (20082003935) and Midcareer Researcher Program (20100027819). | en_US |
dc.language.iso | en | en_US |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA | en_US |
dc.subject | 2-pyrone derivative | en_US |
dc.subject | ionizing radiation | en_US |
dc.subject | mitochondrial cell death | en_US |
dc.subject | reactive oxygen species | en_US |
dc.title | A new 2-pyrone derivative, 5-bromo-3-(3-hydroxyprop-1-ynyl)-2H-pyran-2-one, synergistically enhances radiation sensitivity in human cervical cancer cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 1 | - |
dc.relation.volume | 23 | - |
dc.identifier.doi | 10.1097/CAD.0b013e32834a66ef | - |
dc.relation.page | 43-50 | - |
dc.relation.journal | ANTI-CANCER DRUGS | - |
dc.contributor.googleauthor | Woo, Soo-Jung | - |
dc.contributor.googleauthor | Kim, Min-Jung | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Yoon, Chang-Hwan | - |
dc.contributor.googleauthor | Lim, Eun-Jung | - |
dc.contributor.googleauthor | An, Sungkwan | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Song, Ji-Young | - |
dc.contributor.googleauthor | Kim, In Gyu | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2012200791 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
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