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THE EFFECTS OF SILDENAFIL CITRATE ON CHOROIDAL THICKNESS AS DETERMINED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY

Title
THE EFFECTS OF SILDENAFIL CITRATE ON CHOROIDAL THICKNESS AS DETERMINED BY ENHANCED DEPTH IMAGING OPTICAL COHERENCE TOMOGRAPHY
Author
성민철
Keywords
central serous chorioretinopathy; choroidal thickness; enhanced depth imaging optical coherence tomography (OCT); sildenafil; spectral-domain OCT; CENTRAL SEROUS CHORIORETINOPATHY; OCULAR BLOOD-FLOW; RETINAL VASODILATATION; HEALTHY-SUBJECTS; VIAGRA; HEMODYNAMICS; CIRCULATION; INHIBITORS; PERFUSION; THERAPY
Issue Date
2011-09
Publisher
LIPPINCOTT WILLIAMS & WILKINS, 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
Citation
Retina, Vol.31, No.2 [2011], p332-335
Abstract
Purpose: To investigate the effects of the phosphodiesterase-5 inhibitor, sildenafil citrate, on choroidal thickness using eye-tracked enhanced depth imaging spectral-domain optical coherence tomography.Methods: In a prospective interventional study, 8 healthy subjects (4 men and 4 women) with no ocular history underwent enhanced depth imaging spectral-domain optical coherence tomography at baseline, 1 hour, and 3 hours after the ingestion of 100 mg of sildenafil citrate. Choroidal thickness measurements for both eyes using enhanced depth imaging spectral-domain optical coherence tomography were taken by 2 masked readers at baseline, 1-hour, and 3-hour time points. Statistical analysis was performed to compare the measurements of choroidal thickness at each of the three intervals.Results: The mean age of the subjects was 35.9 years (range 30-46 years). Mean choroidal thickness at baseline was 334 mu m (+/- 57 mu m). Mean choroidal thickness increased by 12.3% to 375 mu m (+/- 68 mu m) at 1 hour after ingestion (P < 0.001). At 3 hours after ingestion, the mean choroidal thickness remained elevated at 372 mu m (+/- 61 mu m), 11.6% thicker than baseline (P < 0.001). There was no significant difference in choroidal thickness between the 1-hour and the 3-hour intervals (P = 0.719).Conclusion: Sildenafil citrate appears to increase choroidal thickness as measured by eye-tracked enhanced depth imaging spectral-domain optical coherence tomography measurements in healthy subjects 1 hour and 3 hours after ingestion. These findings may be of relevance given that increased choroidal thickness appears to be a risk factor for central serous chorioretinopathy and that several reports have suggested an association between phosphodiesterase-5 inhibitors and this disorder.RETINA 31: 332-335, 2011
URI
http://insights.ovid.com/crossref?an=00006982-201102000-00018http://hdl.handle.net/20.500.11754/36983
ISSN
0275-004X
DOI
10.1097/IAE.0b013e3181eef0ae
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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