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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

Title
Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs
Author
고성호
Keywords
Magnetic; Nanovectors; Gene delivery; Stem cell; Solvent shifting; MESENCHYMAL STEM-CELLS; NEURAL STEM; NANOPARTICLES; NANOHYBRIDS; BRAIN; NANOPRECIPITATION; TRANSPLANTATION; TRACKING; CANCER; RATS
Issue Date
2011-09
Publisher
ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Citation
Biomaterials, Vol.32, No.26 [2011], p6174-6182
Abstract
The synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe(2)O(4) nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe(2)O(4) nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke model. (C) 2011 Elsevier Ltd. All rights reserved.
URI
https://www.sciencedirect.com/science/article/pii/S0142961211003899?via%3Dihub
ISSN
0142-9612
DOI
10.1016/j.biomaterials.2011.04.007
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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