5-Day repeated inhalation and 28-day post-exposure study of graphene

Title
5-Day repeated inhalation and 28-day post-exposure study of graphene
Author
안강호
Keywords
Nano-structured materials; nanoparticles; nanotoxicology; particle toxicology; toxicology; WALL CARBON NANOTUBES; SHORT-TERM INHALATION; LUNG-CELLS; OXIDE; EXPOSURE; NANOPLATELETS; NANOMATERIALS; GENOTOXICITY; TOXICITY; MWCNTS
Issue Date
2015-06
Publisher
TAYLOR & FRANCIS LTD
Citation
NANOTOXICOLOGY, v. 9, No. 8, Page. 1023-1031
Abstract
Graphene has recently been attracting increasing attention due to its unique electronic and chemical properties and many potential applications in such fields as semiconductors, energy storage, flexible electronics, biosensors and medical imaging. However, the toxicity of graphene in the case of human exposure has not yet been clarified. Thus, a 5-day repeated inhalation toxicity study of graphene was conducted using a nose-only inhalation system for male Sprague-Dawley rats. A total of three groups (20 rats per group) were compared: (1) control (ambient air), (2) low concentration (0.68 +/- 0.14 mg/m(3) graphene) and (3) high concentration (3.86 +/- 0.94 mg/m(3) graphene). The rats were exposed to graphene for 6 h/day for 5 days, followed by recovery for 1, 3, 7 or 28 days. The bioaccumulation and macrophage ingestion of the graphene were evaluated in the rat lungs. The exposure to graphene did not change the body weights or organ weights of the rats after the 5-day exposure and during the recovery period. No statistically significant difference was observed in the levels of lactate dehydrogenase, protein and albumin between the exposed and control groups. However, graphene ingestion by alveolar macrophages was observed in the exposed groups. Therefore, these results suggest that the 5-day repeated exposure to graphene only had a minimal toxic effect at the concentrations and time points used in this study.
URI
http://www.tandfonline.com/doi/abs/10.3109/17435390.2014.998306http://hdl.handle.net/20.500.11754/36377
ISSN
1743-5390; 1743-5404
DOI
10.3109/17435390.2014.998306
Appears in Collections:
COLLEGE OF ENGINEERING SCIENCES[E](공학대학) > MECHANICAL ENGINEERING(기계공학과) > Articles
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