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dc.contributor.author최한곤-
dc.date.accessioned2018-02-08T04:18:10Z-
dc.date.available2018-02-08T04:18:10Z-
dc.date.issued2015-05-
dc.identifier.citationRSC ADVANCES, v. 5, No. 54, Page. 43687-43694en_US
dc.identifier.issn2046-2069-
dc.identifier.urihttp://pubs.rsc.org/-/content/articlehtml/2015/ra/c5ra05656j-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/36151-
dc.description.abstractTo develop a novel solid lipid nanoparticles (SLNs)-loaded dual-reverse thermosensitive nanomicelle (DRTN) for intramuscular administration of flurbiprofen with sustained release and reduced toxicity, the DRTN was prepared with flurbiprofen-loaded SLNs, poloxamer 407 (P 407), poloxamer 188 (P 188) and water. Its rheological characterization, release, stability, pharmacokinetics and morphology were evaluated after intramuscular administration to rats. These SLNs were solid at 25 degrees C and transformed into liquid form at physiological temperature due to their melting point of about 32 degrees C. Furthermore, the DRTN retained a liquid state at 25 degrees C and gelled inside the body owing to its gelation temperature of about 34.7 degrees C, leading to an opposite reversible property of the SLNs. When compared to the hydrogel, it significantly decreased the drug release and exhibited a reduced initial fast release. It sustained a high plasma concentration for 60 h, which was significantly higher when compared to the suspension, indicating enhanced bioavailability. However, it showed a lower plasma concentration, AUC, and C-max values than that found for the hydrogel, suggesting the retarded release and decreased side effects of the drug. Unlike the hydrogel, it induced no injury to rat muscle as a result of no direct contact of the drug. It was stable for four months. Therefore, this novel DRTN system could be a strong candidate for the intramuscular administration of flurbiprofen.en_US
dc.description.sponsorshipThis work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (no. 2012R1A2A2A01045658).en_US
dc.language.isoen_USen_US
dc.publisherROYAL SOC CHEMISTRYen_US
dc.subjectDRUG-DELIVERY SYSTEMen_US
dc.subjectSKELETAL-MUSCLEen_US
dc.subjectHYDROGELen_US
dc.subjectSTABILITYen_US
dc.subjectBIOAVAILABILITYen_US
dc.subjectMICROSPHERESen_US
dc.subjectDISSOLUTIONen_US
dc.subjectFORMULATIONen_US
dc.subjectMICEen_US
dc.subjectGELen_US
dc.titleDevelopment of a novel solid lipid nanoparticles-loaded dual-reverse thermosensitive nanomicelle for intramuscular administration with sustained release and reduced toxicityen_US
dc.typeArticleen_US
dc.relation.no54-
dc.relation.volume5-
dc.identifier.doi10.1039/c5ra05656j-
dc.relation.page43687-43694-
dc.relation.journalRSC ADVANCES-
dc.contributor.googleauthorDin, FU-
dc.contributor.googleauthorRashid, R-
dc.contributor.googleauthorMustapha, O-
dc.contributor.googleauthorKim, DW-
dc.contributor.googleauthorPark, JH-
dc.contributor.googleauthorKu, SK-
dc.contributor.googleauthorOh, YK-
dc.contributor.googleauthorKim, JO-
dc.contributor.googleauthorYung, YS-
dc.contributor.googleauthorYong, CS-
dc.relation.code2015011569-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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