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Expression of activated HER2 in human testes

Title
Expression of activated HER2 in human testes
Author
신인철
Keywords
Germ cells; HER2; human; soma; testis; tyrosine phosphorylated
Issue Date
2011-06
Publisher
ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
Citation
FERTILITY AND STERILITY; JUN 2011, 95 8, p2725-p2728, 4p.
Abstract
The her2 messenger RNA (mRNA) was the most abundant among the erb type-1 tyrosine kinase receptors mRNA in human testis and was statistically significantly decreased in impaired spermatogenesis. Testicular HER2 was tyrosine phosphorylated and strongly expressed in spermatogonia, early spermatocytes, elongating/elongated spermatids, Sertoli cells, Leydig cells, and peritubular cells, suggesting that activated HER2 participates in mitosis and meiotic entry of germ cells, spermiogenesis, and steroidogenesis via mediating the epidermal growth factor-growth factor signaling. (Fertil Steril (R) 2011;95:2725-8. (C)2011 by American Society for Reproductive Medicine.)
URI
http://www.sciencedirect.com/science/article/pii/S001502821100656X?_rdoc=1&_fmt=high&_origin=gateway&_docanchor=&md5=b8429449ccfc9c30159a5f9aeaa92ffbhttp://www.fertstert.org/article/S0015-0282(11)00656-X/fulltext
ISSN
0015-0282
DOI
10.1016/j.fertnstert.2011.04.043
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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