Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이수재 | - |
dc.date.accessioned | 2018-02-07T08:55:18Z | - |
dc.date.available | 2018-02-07T08:55:18Z | - |
dc.date.issued | 2011-07 | - |
dc.identifier.citation | FEBS LETTERS 권: 585 호: 14 페이지: 2331-2338 | en_US |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.05.070/full | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/36024 | - |
dc.description.abstract | A subpopulation of cancer cells with stem cell properties is responsible for tumor formation, maintenance, and malignant progression; however, the molecular mechanisms underlying the maintenance of cancer stem-like cell properties have remained unclear. Here, we show that the Rho family GTPase Rac1 is involved in the glioma stem-like cell (GSLC) maintenance and tumorigenicity in human glioma. The Rac1-Pak signaling was markedly activated in GSLCs. Knockdown of Rac1 caused reduction of expression of GSLC markers, self-renewal-related proteins and neurosphere formation. Moreover, down-regulation of Rac1 suppressed the migration, invasion, and malignant transformation in GSLCs. Furthermore, inhibition of Rac1 enhanced radiation sensitivity of GSLCs. These results indicate that the small GTPase Rac1 is involved in the maintenance of stemness and malignancies in GSLCs. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. | en_US |
dc.description.sponsorship | This work was supported by the Korea Research Foundation (KRF) and Ministry of Education, Science and Technology (MEST), Korean government, through its National Nuclear Technology Program (2008-2003935) and Medical Research Center Program (2010-0029504). | en_US |
dc.language.iso | en | en_US |
dc.publisher | ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS | en_US |
dc.subject | Rac1 | en_US |
dc.subject | Glioma stem-like cells | en_US |
dc.subject | Migration and invasion | en_US |
dc.subject | Radiation resistance | en_US |
dc.title | The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells | en_US |
dc.type | Article | en_US |
dc.relation.no | 14 | - |
dc.relation.volume | 585 | - |
dc.identifier.doi | 10.1016/j.febslet.2011.05.070 | - |
dc.relation.page | 2331-2338 | - |
dc.relation.journal | FEBS LETTERS | - |
dc.contributor.googleauthor | Yoon, Chang-Hwan | - |
dc.contributor.googleauthor | Hyun, Kyung-Hwan | - |
dc.contributor.googleauthor | Kim, Rae-Kwon | - |
dc.contributor.googleauthor | Lee, Hyejin | - |
dc.contributor.googleauthor | Lim, Eun-Jung | - |
dc.contributor.googleauthor | Chung, Hee-Yong | - |
dc.contributor.googleauthor | An, Sungkwan | - |
dc.contributor.googleauthor | Park, Myung-Jin | - |
dc.contributor.googleauthor | Suh, Yongjoon | - |
dc.contributor.googleauthor | Lee, Su-Jae | - |
dc.relation.code | 2011203177 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF NATURAL SCIENCES[S] | - |
dc.sector.department | DEPARTMENT OF LIFE SCIENCE | - |
dc.identifier.pid | sj0420 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.