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The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells

Title
The small GTPase Rac1 is involved in the maintenance of stemness and malignancies in glioma stem-like cells
Author
이수재
Keywords
Rac1; Glioma stem-like cells; Migration and invasion; Radiation resistance
Issue Date
2011-07
Publisher
ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
Citation
FEBS LETTERS 권: 585 호: 14 페이지: 2331-2338
Abstract
A subpopulation of cancer cells with stem cell properties is responsible for tumor formation, maintenance, and malignant progression; however, the molecular mechanisms underlying the maintenance of cancer stem-like cell properties have remained unclear. Here, we show that the Rho family GTPase Rac1 is involved in the glioma stem-like cell (GSLC) maintenance and tumorigenicity in human glioma. The Rac1-Pak signaling was markedly activated in GSLCs. Knockdown of Rac1 caused reduction of expression of GSLC markers, self-renewal-related proteins and neurosphere formation. Moreover, down-regulation of Rac1 suppressed the migration, invasion, and malignant transformation in GSLCs. Furthermore, inhibition of Rac1 enhanced radiation sensitivity of GSLCs. These results indicate that the small GTPase Rac1 is involved in the maintenance of stemness and malignancies in GSLCs. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
URI
http://onlinelibrary.wiley.com/doi/10.1016/j.febslet.2011.05.070/fullhttp://hdl.handle.net/20.500.11754/36024
ISSN
0014-5793
DOI
10.1016/j.febslet.2011.05.070
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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