90 0

한국인 류마티스관절염 환자에서 항 TNF 제제의 지속성에 관한 연구

Title
한국인 류마티스관절염 환자에서 항 TNF 제제의 지속성에 관한 연구
Other Titles
Treatment Persistence with TNF Blocker in Korean Rheumatoid Arthritis Patients
Author
김태환
Keywords
Rheumatoid arthritis; TNF-blocker; Drug persistency
Issue Date
2011-12
Publisher
대한류마티스학회
Citation
Journal of Rheumatic Diseases, 2011, 18(3), P.161-167(7)
Abstract
Objective. To estimate drug persistency and the safety of TNF blocker in Korean patients with rheumatoid arthritis. Methods. Data were extracted from medical records of rheumatoid arthritis patients who had treated with TNF blocker or are currently using TNF blocker at Hanyang University Hospital for Rheumatic Diseases from December 2000 to November 2009 (REtrospective study for Safety and Efficacy of Anti-RA treatment with biologiCs, RESEARCh). Comprehensive chart reviews were undertaken on all patients and data on drug usages and response of TNF blocker was collected at initiation, 3 months and the time of data collection. Persistency with treatment was examined using life-table analysis and multivariate Cox proportional hazard models were developed to examine potential predictors of discontinuation of TNF blocker. Result. A total of 268 patients were enrolled in this retrospective study. Among them 180 patients were included in the analysis of drug persistency. The 1-year and 5-year drug persistency of TNF blocker was 74% and 46%, respectively. Concomitant use of methotrexate (hazard ratio 0.46, 95% CI 0.27-0.80) was associated with higher persistence. Comparing to etanercept, adalimumab is an independent risk factor for discontinuation (hazard ratio 2.63, 95% CI 1.43-4.84). Conclusion. Five-year drug persistency of TNF blocker was 46% and concomitant use of methotrexate is associated with higher persistence.
URI
https://synapse.koreamed.org/DOIx.php?id=10.4078/jrd.2011.18.3.161
ISSN
2093-940X
DOI
10.4078/jrd.2011.18.3.161
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE