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dc.contributor.author최한곤-
dc.date.accessioned2018-02-07T06:34:17Z-
dc.date.available2018-02-07T06:34:17Z-
dc.date.issued2015-04-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v. 38, No. 4, Page. 522-533en_US
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://link.springer.com/article/10.1007/s12272-014-0399-0-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/35897-
dc.description.abstractThe purpose of this study was to improve the gastric solubility and bioavailability of rebamipide (RBM) by preparing the RBM solid dispersion tablet (RBM-SDT) from solid dispersion powder prepared by spray-drying technique. For preparation of rebamipide solid dispersions (RBM-SDs), solubility study was performed in various hydrophilic carriers and alkalizers, among which sodium alginate and sodium carbonate were selected as the hydrophilic polymer and alkalizer, respectively. Different combinations of drug-polymer-alkalizer were dissolved in aqueous solution and spray-dried in order to obtain solid dispersions. Noticeable improvement in aqueous solubility (approximately 200 times) and in vitro dissolution rate was observed by RBM-SDs, compared to RBM powder. The optimized formulation of RBM-SD powder consisted of RBM powder/sodium alginate/sodium carbonate at the weight ratio of 1/2/2. The transformation of crystalline RBM to amorphous RBM-SD powder was clearly demonstrated by powder X-ray diffraction, differential scanning calorimetry (DSC) and scanning electron microscopy. The optimized RBM-SD was formulated in tablet dosage form, containing approximately 2 % sodium lauryl sulphate and poloxamer F68 as wetting agents. The RBM-SDT exhibited enhanced dissolution in hydrochloric acid buffer (pH 1.2) and distilled water. Moreover, pharmacokinetic study in rats showed higher AUC and C-max for RBM-SDT than those for RBM powder and commercial product. Thus, the developed RBM-SDT formulation can be more efficacious for improving oral bioavailability of RBM.en_US
dc.description.sponsorshipThis study was supported by a grant from the Medical Cluster R&D Support Project of Daegu Gyeongbuk Medical Innovation Foundation, Republic of Korea (2013) (No. HT13C0011).en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOC KOREAen_US
dc.subjectRebamipideen_US
dc.subjectSolubilityen_US
dc.subjectSolid dispersionen_US
dc.subjectSpray-dryingen_US
dc.subjectBioavailabilityen_US
dc.subjectSPRAY-DRYING TECHNIQUEen_US
dc.subjectIN-VIVO EVALUATIONen_US
dc.subjectENHANCED BIOAVAILABILITYen_US
dc.subjectSOLUBLE DRUGSen_US
dc.subjectBETA-CYCLODEXTRINen_US
dc.subjectSALT FORMen_US
dc.subjectABSORPTIONen_US
dc.subjectRELEASEen_US
dc.subjectPHen_US
dc.subjectINCLUSIONen_US
dc.titleDevelopment of a rebamipide solid dispersion system with improved dissolution and oral bioavailabilityen_US
dc.typeArticleen_US
dc.relation.no4-
dc.relation.volume38-
dc.identifier.doi10.1007/s12272-014-0399-0-
dc.relation.page522-533-
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH-
dc.contributor.googleauthorPradhan, R-
dc.contributor.googleauthorTran, TH-
dc.contributor.googleauthorChoi, JY-
dc.contributor.googleauthorChoi, IS-
dc.contributor.googleauthorChoi, HG-
dc.contributor.googleauthorYong, CS-
dc.contributor.googleauthorKim, JO-
dc.relation.code2015009399-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidhangon-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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