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dc.contributor.author방소영-
dc.date.accessioned2018-02-07T06:06:29Z-
dc.date.available2018-02-07T06:06:29Z-
dc.date.issued2011-07-
dc.identifier.citationJOINT BONE SPINE,Vol.79 No.3 [2012],271-273en_US
dc.identifier.issn1297-319X-
dc.identifier.issn1778-7254-
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1297319X11001448-
dc.description.abstractObjectiveBrachydactyly (BD) is a general term for inappropriately short fingers and/or toes. The author previously reported that a short metacarpal bone had a protective effect on the metacarpophalangeal joint of the same finger in rheumatoid arthritis (RA). The objective was to investigate the prevalence of BD in patients with RA and its potential effect on the phenotype, especially erosive changes.MethodsA total of 1524 Korean patients with RA were recruited. The presence of BD on hand radiographs, rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (anti-CCP), HLA-DRB1 shared epitopes (SE), risk haplotypes of peptidyl deiminase type IV (PADI4) and erosive joint stage, and smoking status, were determined.ResultsThe prevalence of BD was 7.9% (n = 120) in our RA cohort. The types of BD were type A3 (79.2%), type D (15.0%), Kirner deformity (14.2%), and type E (6.7%). RA patients with BD had reduced erosion on hand radiographs (OR = 0.57, 95% CI: 0.34?0.95, p = 0.029) adjusted for age, sex, disease duration, smoking, RF, anti-CCP, SE, and PADI4.ConclusionBD is more common in RA patients than might be expected. BD may have a protective effect on erosive changes in RA independent of previously well-established risk factors such as seropositivity, SE, PADI4, and smoking.en_US
dc.language.isoenen_US
dc.publisherElsevier Science B.V., Amsterdam.en_US
dc.subjectBrachydactylyen_US
dc.subjectHOXD geneen_US
dc.subjectRheumatoid arthritisen_US
dc.titleDoes brachydactyly have a protective effect on the erosive changes in rheumatoid arthritis?en_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.jbspin.2011.05.022-
dc.relation.page1-3-
dc.relation.journalJOINT BONE SPINE-
dc.contributor.googleauthorBang, S.-Y.-
dc.contributor.googleauthorKim, T.-H.-
dc.contributor.googleauthorBae, S.-C.-
dc.contributor.googleauthorJun, J.-B-
dc.relation.code2011204537-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidsybang-
dc.classification.keywordRheumatoid arthritis-
dc.classification.keywordBrachydactyly-
dc.classification.keywordHOXD gene-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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