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A Case of Dowling-Degos Disease on the Vulva

Title
A Case of Dowling-Degos Disease on the Vulva
Author
김정수
Keywords
Dowling-Degos disease; Pigmented skin lesion; Vulva; FLEXURES
Issue Date
2011-05
Publisher
KOREAN DERMATOLOGICAL ASSOC, 305 SEOCHO NASAN, SUITE OFFICE 1330-16, SEOCHO-2-DONG, SEOCHO-GU, SEOUL, 137-858, SOUTH KOREA
Citation
ANNALS OF DERMATOLOGY; MAY 2011, 23 2, p205-p208, 4p.
Abstract
Dowling-Degos disease (DDD) is an autosomal dominant genodermatosis and this disease is a genetically determined disturbance of epidermal proliferation. It is characterized by acquired, slowly progressive pigmented lesions that primarily involve the great skin folds and flexural areas such as the axilla, neck, limb flexures, the inframammary area and the inguinal folds. The vulva is an unusual location for DDD. A 41-year-old woman presented with a 10-year history of multiple, small, reticulated and brownish macules distributed symmetrically on the bilateral external genital regions. We found no other similarly pigmented skin lesions on her body, including the flexural areas. There was no known family history of similar eruptions or pigmentary changes. The histologic examination showed irregular rete ridge elongation with a filiform or antler-like pattern and basilar hyperpigmentation on the tips. Fontana-Masson staining showed increased pigmentation of the rete ridges and the S100 protein staining did not reveal an increased number of melanocytes in the epidermis. From these findings, we diagnosed this lesion as DDD. (Ann Dermatol 23(2) 205 similar to 208, 2011)
URI
https://synapse.koreamed.org/DOIx.php?id=10.5021/ad.2011.23.2.205
ISSN
1013-9087
DOI
10.5021/ad.2011.23.2.205
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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