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Brief review of the role of glycogen synthase kinase-3beta in amyotrophic lateral sclerosis

Title
Brief review of the role of glycogen synthase kinase-3beta in amyotrophic lateral sclerosis
Author
고성호
Keywords
Neurology; Diseases of the nervous system; RC346-429
Issue Date
2011-04
Publisher
Hindawi Publishing Corporation
Citation
Neurology Research International,2011
Abstract
Glycogen synthase kinase-3β (GSK-3β) is known to affect a diverse range of biological functions controlling gene expression, cellular architecture, and apoptosis. GSK-3β has recently been identified as one of the important pathogenic mechanisms in motor neuronal death related to amyotrophic lateral sclerosis (ALS). Therefore, the development of methods to control GSK-3β could be helpful in postponing the symptom progression of ALS. Here we discuss the known roles of GSK-3β in motor neuronal cell death in ALS and the possibility of employing GSK-3β modulators as a new therapeutic strategy.
URI
https://www.hindawi.com/journals/nri/2011/205761/
ISSN
2090-1852; 2090-1860
DOI
10.1155/2011/205761
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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