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Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough

Title
Measurement of Nasal Nitric Oxide Is Useful for the Diagnosis of Sinusitis-Induced Prolonged Cough
Author
김태형
Keywords
prolonged cough; nasal nitric oxide; upper airway cough syndrome; sinusitis
Issue Date
2011-02
Publisher
TOHOKU UNIV MEDICAL PRESS, 2-1, SEIRYO-MACHI, AOBA-KU, SENDAI, MIYAGI 980-8575, JAPAN
Citation
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE; FEB 2011, 223 2, p145-p151, 7p.
Abstract
Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of nitric oxide in nasal cavity air (nNO) is influenced by allergic rhinitis and/or sinusitis, both of which are common causes of UACS. We measured nNO levels in patients with UACS and those with other causes. We also examined the usefulness of measuring nNO for differentiating patients with sinusitis from those without sinusitis. The study included 93 adult patients with prolonged cough lasting more than three weeks. Etiologies of cough were identified and nNO was measured at the initial investigation. UACS was diagnosed in 58 patients (62.4%), and sinusitis was identified in 11(19.0%) of the 58 patients with UACS. Levels of nNO in UACS did not differ from non-UACS etiologies (316.2 +/- 129.2 vs. 334.9 +/- 88.2 ppb; p = 0.452), suggesting that the measurement of nNO could not discriminate UACS from other etiologies of prolonged cough. However, patients with sinusitis showed significantly decreased nNO levels (190.1 +/- 114.8 ppb) compared with patients with UACS without sinusitis (345.7 +/- 114.6 ppb; p < 0.001) and non-UACS patients (334.9 +/- 88.2 ppb; p < 0.001). In a receiver operating characteristic curve analysis for the diagnosis of sinusitis in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a nNO cutoff value of 279.0 ppb. These findings imply that the measurement of nNO could be useful for diagnosis of prolonged cough associated with sinusitis.
URI
https://www.jstage.jst.go.jp/article/tjem/223/2/223_2_145/_articlehttp://hdl.handle.net/20.500.11754/35519
ISSN
0040-8727
DOI
10.1620/tjem.223.145
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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