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Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management

Title
Interactions between herbs and antidiabetics: an overview of the mechanisms, evidence, importance, and management
Author
Choe, Kevin Kyungsik
Keywords
Herb-drug interaction; Antidiabetics; Mechanism; Evidence; Management; ST-JOHNS-WORT; INDUCED DIABETIC-RATS; GINKGO-BILOBA EXTRACT; HUMAN CYTOCHROME-P450 3A4; LOWER PLASMA-GLUCOSE; IN-VITRO EVALUATION; HUMAN LIVER-MICROSOMES; PREGNANE X RECEPTOR; KOREAN RED GINSENG; GLYCOPROTEIN P-GP
Issue Date
2015-07
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v. 38, No. 7, Page. 1281-1298
Abstract
Complementary and alternative therapies are quickly gaining importance because they are perceived to be free of side effects due to their natural origin. However, herbal remedies are complex mixtures of bioactive entities, which may interact with prescription drugs through pharmacokinetic or pharmacodynamic mechanisms and sometimes result in life-threatening consequences. In particular, diabetes patients are often treated with multiple medications due to different comorbidities, and such patients use antidiabetic medications for their entire lives; thus, it is important to make the public aware of herb interactions with antidiabetic drugs. In this paper, we summarize the reports available on the interaction of herbal remedies with oral hypoglycemic agents and describe mechanisms, preclinical or clinical evidence, importance, and management strategies.
URI
https://link.springer.com/article/10.1007/s12272-014-0517-zhttp://hdl.handle.net/20.500.11754/35394
ISSN
0253-6269; 1976-3786
DOI
10.1007/s12272-014-0517-z
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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