68 0

Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury

Title
Protective Activity of Dendropanax Morbifera Against Cisplatin-Induced Acute Kidney Injury
Author
배옥남
Keywords
Nephrotoxicity; Cisplatin; Acute kidney injury; Dendropanax morbifera; ACUTE TUBULAR-NECROSIS; ANTICOMPLEMENT ACTIVITY; INDUCED NEPHROTOXICITY; CELL-DEATH; MECHANISMS; LEVEILLE; RATS; TRANSPORTERS; QUERCETIN; TOXICITY
Issue Date
2015-01
Publisher
KARGER
Citation
KIDNEY & BLOOD PRESSURE RESEARCH, v. 40, No. 1, Page. 1-12
Abstract
Background/Aims: Drug-induced acute kidney injury (AKI) has been a severe threat to hospitalized patients, raising the urgent needs to develop strategies to reduce AKI. We investigated the protective activity of Dendropanax morbifera (DP), a medicinal plant which has been widely used to treat infectious and pain diseases, on acute kidney injury (AKI) using cisplatin-induced nephropathic models. Methods: Both in vitro renal tubular cells (NRK-52E) and in vivo rat models were used to demonstrate the nephroprotective effect of DP. Results: Methanolic extract from DP significantly reduced cisplatin-induced toxicity in renal tubular cells. Through successive liquid extraction, the extract of DP was separated into n-hexane, CHCl3, EtOAc, n-BuOH, and H2O fractions. Among these, the CHCl3 fraction (DPCF) was found to be most potent. The protective activity of DPCF was found to be mediated through anti-oxidant, mitochondrial protective, and anti-apoptotic activities. In in vivo rat models of AKI, treatment with DPCF significantly reversed the cisplatin-induced increase in blood urea nitrogen and serum creatinine and histopathologic damage, recovered the level of anti-oxidant enzymes, and inhibited renal apoptosis. Conclusion: We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.
URI
https://www.karger.com/Article/Abstract/368466http://hdl.handle.net/20.500.11754/35383
ISSN
1420-4096; 1423-0143
DOI
10.1159/000368466
Appears in Collections:
COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE