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종양괴사인자 차단제 사용 후 발생한 사르코이드증 1예

Title
종양괴사인자 차단제 사용 후 발생한 사르코이드증 1예
Other Titles
A Case of Development of Sarcoidosis During Tumor Necrosis Factor-alpha Antagonist Therapy
Author
백승삼
Keywords
종양괴사인자차단제; 사르코이드증; Tumor necrosis factor-alpha antagonist; Ankylosing spondylitis; Tumor necrosis factor-α antagonist; Sarcoidosis
Issue Date
2011-04
Publisher
대한류마티스학회
Citation
Journal of Rheumatic Diseases, 2011, 18(1), P.41-45
Abstract
Etanercept is a soluble receptor fusion protein that inhibits tumor necrosis factor-alpha(TNF-α). The receptor is used widely in the treatment of ankylosing spondylitis, rheumatoid arthritis, sarcoidosis and other indications. For sarcoidosis, it potentially suppresses granuloma formation with TNF-α blocking. On the other hand, recent studies have suggested that paradoxical sarcoidosis can be induced by TNF-α antagonists in some cases. A 42-yearold woman, who was treated with etanercept due to ankylosing spondylitis for 5 years, was admitted because of right suprahilar lymphadenopathy on chest radiography. Chest computed tomography revealed an enlargement of supraclavicular, paratracheal, mediastinal lymph nodes. She was diagnosed with sarcoidosis on the supraclavicular lymph node biopsy, which was non-caseating epithelioid cell granuloma and excluded from similar diseases. She was treated for sarcoidosis with prednisolone instead of etanercept.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2897964
ISSN
1226-8070
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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