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류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현

Title
류마티스관절염 활액 대식세포에서 파골세포 분화 관련 유전자의 발현
Other Titles
Original Articles : Expression of Osteoclastogenesis-related Genes in Rheumatoid Arthritis Synovial Macrophages
Author
김태환
Keywords
류마티스관절염; 활액대식세포; 파골세포; 분화; 유전자; Synovial osteoclast precursors; Osteoclastogenesis; Rheumatoid arthritis
Issue Date
2011-03
Publisher
대한류마티스학회
Citation
Journal of Rheumatic Diseases, 2011, 18(1), P.11-18
Abstract
To examine the mechanism for the inhibited differentiation of osteoclasts in rheumatoid arthritis synovial CD14+ osteoclast precursors, the different expressions of the osteoclastogenesis-related genes in rheumatoid arthritis (RA) synovial fluid CD14+ osteoclast precursors were compared with those of normal peripheral blood (PB) CD14+ osteoclast precursors. Methods. The expression of osteoclastogenesis-related genes were examined using a gene expression oligonucleotide microarray. To validate the results of the microarray analysis, the mRNA expressions of osteoclastogenesis-related genes were measured by real-time PCR. Results. Comparative analysis of the mRNA profiles showed significantly different expression of osteoclastogenesis-related genes, such as MafB, Id3 and LILRB4, in the RA synovial CD14+ osteoclast precursors, compared to that of normal PB CD14+ osteoclast precursors. Conclusion. The expression of the osteoclastogenesis-related genes in RA synovial CD14+ osteoclast precursors is different from that of the normal PB CD14+ osteoclast precursors. These results suggest that the different expression of osteoclastogenesis-related genes might be involved in the altered osteoclastogenesis in RA synovial osteoclast precursors.
URI
http://kiss.kstudy.com/thesis/thesis-view.asp?key=2897959
ISSN
2093-940X
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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