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Calcineurin may regulate multiple endocytic processes in C. elegans

Title
Calcineurin may regulate multiple endocytic processes in C. elegans
Author
안주홍
Keywords
Calcineurin; C. elegans; Endocytosis; Intestine; Synaptic vesicle recycling
Issue Date
2011-02
Publisher
Korean SOC Biochemistry & Molecular Biology
Citation
BMB Reports, 2011, 44(2), P.96-101
Abstract
Calcineurin is a serine/threonine protein phosphatase controlled by Ca2+ and calmodulin that has been implicated in various signaling pathways. Previously, we reported that calcineurin regulates coelomocyte endocytosis in Caenorhabditis elegans. So far, simple and powerful in vivo approaches have been developed to study various endocytic processes in C elegans. Using these in vivo assays, we further analyzed the endocytic phenotypes of calcineurin mutants. We observed that the calcineurin mutants were defective in apical endocytosis in the intestine as well as synaptic vesicle recycling in the nerve cord. However, we found that calcineurin mutants displayed normal receptor-mediated endocytosis in oocytes. Therefore, our results suggest that calcineurin may regulate specific sets of endocytic processes in nematode. [BMB reports 2011; 44(2): 96-101]
URI
http://koreascience.or.kr/article/ArticleFullRecord.jsp?cn=E1MBB7_2011_v44n2_96
ISSN
1225-8687; 1976-6696
DOI
10.5483/BMBRep.2011.44.2.96
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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