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dc.contributor.author주재범-
dc.date.accessioned2018-02-02T06:43:19Z-
dc.date.available2018-02-02T06:43:19Z-
dc.date.issued2011-04-
dc.identifier.citationANALYTICAL CHEMISTRY, v. 83, NO. 8, Page. 3076-3081en_US
dc.identifier.issn0003-2700-
dc.identifier.urihttps://pubs.acs.org/doi/abs/10.1021/ac103329b-
dc.description.abstractThe development of ultrafast Raman-based detection is one of the most interesting challenges underpinning the application of droplet based microfluidics. Herein, we describe the use of surface-enhanced resonance Raman spectroscopy (SERRS) with submillisecond time resolution as a powerful detection tool in microdroplet reactors. Individual droplets containing silver nanoparticle aggregates functionalized with Raman reporters are interrogated and characterized by full spectra acquisitions with high spatial resolution in real time. Whereas previous works coupling SERRS with droplet-based microfluidics acquire a single spectrum over single or multiple droplets, we build upon these results by increasing our temporal resolution by 2 orders of magnitude. This allows us to interrogate multiple points within one individual droplet. The SERRS signals emitted from the aggregates are utilized to access the influence of flow rate on droplet size and throughput. Accordingly, our approach allows for high-throughput analysis that facilitates the study of other biological assays or molecular interactions.en_US
dc.description.sponsorshipM.P.C. and J.H. contributed equally to this work. This work was supported by the RCUK Microdroplets Basic Technology Project. The authors also acknowledge the National Research Foundation of Korea (Grant Numbers R11-2009-044-1002-0K20904000004-09A050000410). J.H. acknowledges the Brain Korea 21 Project. The authors acknowledge Prof. David McComb for his useful discussion. M.P.C. and J.H. contributed equally toward this publication.en_US
dc.language.isoenen_US
dc.publisherAMER CHEMICAL SOCen_US
dc.subjectELECTROCHEMICAL DETECTIONen_US
dc.subjectTRIPHENYLMETHANE DYESen_US
dc.subjectLATEST DEVELOPMENTSen_US
dc.subjectMALACHITE GREENen_US
dc.subjectMICRODROPLETSen_US
dc.subjectNANOPARTICLESen_US
dc.subjectGENERATIONen_US
dc.subjectKINETICSen_US
dc.subjectMICROen_US
dc.titleUltrafast Surface Enhanced Resonance Raman Scattering Detection in Droplet-Based Microfluidic Systemsen_US
dc.typeArticleen_US
dc.relation.no8-
dc.relation.volume83-
dc.identifier.doi10.1021/ac103329b-
dc.relation.page3076-3081-
dc.relation.journalANALYTICAL CHEMISTRY-
dc.contributor.googleauthorCecchini, MP-
dc.contributor.googleauthorHong, J-
dc.contributor.googleauthorLim, C-
dc.contributor.googleauthorChoo, J-
dc.contributor.googleauthorAlbrecht, T-
dc.contributor.googleauthorDemello, AJ-
dc.contributor.googleauthorEdel, JB-
dc.relation.code2011200599-
dc.sector.campusS-
dc.sector.daehakGRADUATE SCHOOL[S]-
dc.sector.departmentDEPARTMENT OF BIONANOTECHNOLOGY-
dc.identifier.pidjbchoo-
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GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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