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Ultrafast Surface Enhanced Resonance Raman Scattering Detection in Droplet-Based Microfluidic Systems

Title
Ultrafast Surface Enhanced Resonance Raman Scattering Detection in Droplet-Based Microfluidic Systems
Author
주재범
Keywords
ELECTROCHEMICAL DETECTION; TRIPHENYLMETHANE DYES; LATEST DEVELOPMENTS; MALACHITE GREEN; MICRODROPLETS; NANOPARTICLES; GENERATION; KINETICS; MICRO
Issue Date
2011-04
Publisher
AMER CHEMICAL SOC
Citation
ANALYTICAL CHEMISTRY, v. 83, NO. 8, Page. 3076-3081
Abstract
The development of ultrafast Raman-based detection is one of the most interesting challenges underpinning the application of droplet based microfluidics. Herein, we describe the use of surface-enhanced resonance Raman spectroscopy (SERRS) with submillisecond time resolution as a powerful detection tool in microdroplet reactors. Individual droplets containing silver nanoparticle aggregates functionalized with Raman reporters are interrogated and characterized by full spectra acquisitions with high spatial resolution in real time. Whereas previous works coupling SERRS with droplet-based microfluidics acquire a single spectrum over single or multiple droplets, we build upon these results by increasing our temporal resolution by 2 orders of magnitude. This allows us to interrogate multiple points within one individual droplet. The SERRS signals emitted from the aggregates are utilized to access the influence of flow rate on droplet size and throughput. Accordingly, our approach allows for high-throughput analysis that facilitates the study of other biological assays or molecular interactions.
URI
https://pubs.acs.org/doi/abs/10.1021/ac103329b
ISSN
0003-2700
DOI
10.1021/ac103329b
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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