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dc.contributor.author김태욱-
dc.date.accessioned2018-02-02T06:22:56Z-
dc.date.available2018-02-02T06:22:56Z-
dc.date.issued2011-02-
dc.identifier.citationNATURE CELL BIOLOGY, v. 13, NO 2, Page. 124-49en_US
dc.identifier.issn1465-7392-
dc.identifier.urihttp://www.nature.com/articles/ncb2151-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/35039-
dc.description.abstractWhen brassinosteroid levels are low, the GSK3-like kinase BIN2 phosphorylates and in activates the BZR1 transcription factor to inhibit growth in plants. Brassinosteroid promotes growth by inducing dephosphorylation of BZR1, but the phosphatase that dephosphorylates BZR1 has remained unknown. Here, using tandem affinity purification, we identified protein phosphatase 2A (PP2A) as a BZR1-interacting protein. Genetic analyses demonstrated a positive role for PP2A in brassinosteroid signalling an BZR1 dephosphorylation. Members of the B' regulatory subunits of PP2A directly interact with BZR1's putative PEST domain containing the site of the bzr1-1D mutation. Interaction with and dephosphorylation by PP2A are enhanced by the bzr1-1D mutation, reduced by two intragenic bzr1-1D suppress or mutations, and abolished by deletion of the PEST domain. This study reveals a crucial function for PP2A in dephosphorylating and activating BZR1 and completes the set of core components of the brassinosteroid-signalling cascade from cell surface receptor kinase to gene regulation in the nucleus.en_US
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.subjectPROTEIN PHOSPHATASE 2Aen_US
dc.subjectRECEPTOR KINASE BRI1en_US
dc.subjectSIGNAL-TRANSDUCTIONen_US
dc.subjectBETA-CATENINen_US
dc.subjectTRANSCRIPTION FACTORSen_US
dc.subjectARABIDOPSIS-THALIANAen_US
dc.subjectREGULATORY SUBUNITen_US
dc.subjectPLASMA-MEMBRANEen_US
dc.subjectMECHANISMSen_US
dc.subjectMODULATEen_US
dc.titlePP2A activates brassinosteroid-responsive gene expression and plant growth by dephosphorylating BZR1en_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume13-
dc.identifier.doi10.1038/ncb2151-
dc.relation.page124-49-
dc.relation.journalNATURE CELL BIOLOGY-
dc.contributor.googleauthorTang, Wenqiang-
dc.contributor.googleauthorYuan, Min-
dc.contributor.googleauthorWang, Ruiju-
dc.contributor.googleauthorYang, Yihong-
dc.contributor.googleauthorWang, Chunming-
dc.contributor.googleauthorOses-Prieto, Juan-
dc.contributor.googleauthorKim, Tae-Wuk-
dc.contributor.googleauthorZhou, Hong-Wei-
dc.contributor.googleauthorDeng, Zhiping-
dc.contributor.googleauthorGampala, Srinivas-
dc.relation.code2011206935-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF NATURAL SCIENCES[S]-
dc.sector.departmentDEPARTMENT OF LIFE SCIENCE-
dc.identifier.pidtwgibio-
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
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