139 0

Full metadata record

DC FieldValueLanguage
dc.contributor.author김선정-
dc.date.accessioned2018-02-01T07:46:42Z-
dc.date.available2018-02-01T07:46:42Z-
dc.date.issued2011-01-
dc.identifier.citationBasic & Clinical Pharmacology & Toxicology, 2011, 108(1), P.28-33en_US
dc.identifier.issn1742-7835-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/j.1742-7843.2010.00623.x/abstract?-
dc.description.abstractSulphur mustard (SM) is an alkylating agent whose mechanism is not fully understood. To investigate the early action of SM, we examined the effect of SM on contraction of vascular smooth muscles. Phenylephrine (PE)-induced contraction was reduced by SM, but only marginally by 70 mM KCl-. Additional reduction was induced by nifedipine in SM-treated arteries. In the absence of extracellular Ca2+, contraction of arteries by PE was reduced, which was fully recovered by addition of 2 mM Ca2+. However, recovery was attenuated by pre-treatment with SM. The effect of SM on contraction by PE was not influenced by pre- and post-treatment with Phorbol 12, 13-dibutyrate. Calmodulin kinase II (CaMKII) was implicated as being responsible for the action of SM, because the contractile mechanisms of vascular smooth muscle via both Ca2+-calmodulin-myosin light chain kinase axis and protein kinase C-proline-rich tyrosine kinase axis were not related to the action of SM. Elevation of phosphorylated CaMKII level by Ionomycin or PE was attenuated by treatment of SM on western blot. CaMKII may be a candidate target molecule of SM in early stage contraction of vascular smooth muscle.en_US
dc.description.sponsorshipThe Creative Research Initiative Center for Bio-Artificial Muscle of the Ministry of Education, Science and Technology (MEST) in Korea is acknowledged for support.en_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.subjectHUMAN KERATINOCYTESen_US
dc.subjectRECEPTORen_US
dc.subjectCELLSen_US
dc.subjectINHIBITIONen_US
dc.subjectACTIVATIONen_US
dc.subjectCONSTRICTIONen_US
dc.subjectCHANNELSen_US
dc.subjectARTERIESen_US
dc.subjectRELEASEen_US
dc.subjectCALCIUMen_US
dc.titleInvolvement of Calmodulin Kinase II in the Action of Sulphur Mustard on the Contraction of Vascular Smooth Muscleen_US
dc.typeArticleen_US
dc.relation.no1-
dc.relation.volume108-
dc.identifier.doi10.1111/j.1742-7843.2010.00623.x-
dc.relation.page28-33-
dc.relation.journalBASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY-
dc.contributor.googleauthorMin Tae Kim-
dc.contributor.googleauthorWoo-Jae Park-
dc.contributor.googleauthorShin Kim-
dc.contributor.googleauthorJi Won Lee-
dc.contributor.googleauthorSang Yun Lee-
dc.contributor.googleauthorJu-Hong Jeon-
dc.contributor.googleauthorInsuk So-
dc.contributor.googleauthorByung Joo Kim-
dc.contributor.googleauthorSeon Jeong Kim-
dc.relation.code2011211932-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF ENGINEERING[S]-
dc.sector.departmentDIVISION OF ELECTRICAL AND BIOMEDICAL ENGINEERING-
dc.identifier.pidsjk-
Appears in Collections:
COLLEGE OF ENGINEERING[S](공과대학) > ELECTRICAL AND BIOMEDICAL ENGINEERING(전기·생체공학부) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE