Positive association between striatal serotonin level and abnormal involuntary movements in chronic L-DOPA-treated hemiparkinsonian rats
- Title
- Positive association between striatal serotonin level and abnormal involuntary movements in chronic L-DOPA-treated hemiparkinsonian rats
- Author
- 박장환
- Keywords
- Parkinson's disease; Dopamine; 5-Hydroxytryptamine; Abnormal involuntary movement score; L-DOPA-induced dyskinesia
- Issue Date
- 2011-02
- Publisher
- Elsevier Science LTD
- Citation
- Brain Research Bulletin, 2011, 84(2), P.151-156
- Abstract
- Although L-DOPA represents the standard of care in Parkinson's disease, long-term treatment may be compromised by L-DOPA-induced dyskinesia (LID), with adverse fluctuations in motor responsiveness and progressive loss of control. Here we show that in rats with 6-hydroxydopamine-induced lesions of the median forebrain bundle, LID correlates with 5-HT levels. Rats were
- URI
- https://www.sciencedirect.com/science/article/abs/pii/S0361923010002807
- ISSN
- 0361-9230
- DOI
- 10.1016/j.brainresbull.2010.12.006
- Appears in Collections:
- COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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