Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김철영 | - |
dc.date.accessioned | 2017-12-28T05:37:26Z | - |
dc.date.available | 2017-12-28T05:37:26Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v. 38, NO 6, Page. 1117-1126 | en_US |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12272-014-0511-5 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/34213 | - |
dc.description.abstract | Dendrobium nobile belongs to the Orchidaceae family and is one of the medicinal herbs used in traditional Chinese medicine as a therapeutic agent for gastrointestinal and cardiovascular diseases. In this study, we separated three phenanthrenes (ephemeranthol A (EA), 1,5,7-trimethoxyphenanthren-2-ol (TP), dehydroorchinol (DO)) from D. nobile, and compared their anti-inflammatory activities. TP is a new phenanthrene compound and its structure was determined from H-1, C-13 NMR and HR-ESI-MS data. To analyze the anti-inflammatory activities of the phenanthrenes, Raw 264.7 cells were used, since they are immature-macrophages and easily matured by LPS stimulation. EA and DO showed anti-inflammatory activities in the activated Raw 264.7 cells. That is, we showed that EA is a potent inhibitor of the production of nitric oxide and pro-inflammatory cytokines. The inhibitory activities of phenanthrenes were found to be caused by blockage of NF-kappa B activation and the phosphorylation of MAP kinases in the macrophages. These results are expected to serve as a guide for future studies on the ability of phenanthrenes to inhibit acute and chronic inflammatory diseases. | en_US |
dc.description.sponsorship | This work was supported by the research Grant of the Chungbuk National University in 2013. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | PHARMACEUTICAL SOC KOREA | en_US |
dc.subject | Inflammation; | en_US |
dc.subject | Dendrobium nobile | en_US |
dc.subject | Phenanthrenes | en_US |
dc.subject | Macrophages | en_US |
dc.subject | Ephemeranthol A | en_US |
dc.title | Anti-inflammatory effects of Dendrobium nobile derived phenanthrenes in LPS-stimulated murine macrophages | en_US |
dc.type | Article | en_US |
dc.relation.no | 6 | - |
dc.relation.volume | 38 | - |
dc.identifier.doi | 10.1007/s12272-014-0511-5 | - |
dc.relation.page | 1117-1126 | - |
dc.relation.journal | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.contributor.googleauthor | Kim, JH | - |
dc.contributor.googleauthor | Oh, SY | - |
dc.contributor.googleauthor | Han, SB | - |
dc.contributor.googleauthor | Uddin, GM | - |
dc.contributor.googleauthor | Kim, CY | - |
dc.contributor.googleauthor | Lee, JK | - |
dc.relation.code | 2015009399 | - |
dc.sector.campus | E | - |
dc.sector.daehak | COLLEGE OF PHARMACY[E] | - |
dc.sector.department | DEPARTMENT OF PHARMACY | - |
dc.identifier.pid | chulykim | - |
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