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dc.contributor.author김철영-
dc.date.accessioned2017-12-28T05:37:26Z-
dc.date.available2017-12-28T05:37:26Z-
dc.date.issued2015-06-
dc.identifier.citationARCHIVES OF PHARMACAL RESEARCH, v. 38, NO 6, Page. 1117-1126en_US
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://link.springer.com/article/10.1007/s12272-014-0511-5-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/34213-
dc.description.abstractDendrobium nobile belongs to the Orchidaceae family and is one of the medicinal herbs used in traditional Chinese medicine as a therapeutic agent for gastrointestinal and cardiovascular diseases. In this study, we separated three phenanthrenes (ephemeranthol A (EA), 1,5,7-trimethoxyphenanthren-2-ol (TP), dehydroorchinol (DO)) from D. nobile, and compared their anti-inflammatory activities. TP is a new phenanthrene compound and its structure was determined from H-1, C-13 NMR and HR-ESI-MS data. To analyze the anti-inflammatory activities of the phenanthrenes, Raw 264.7 cells were used, since they are immature-macrophages and easily matured by LPS stimulation. EA and DO showed anti-inflammatory activities in the activated Raw 264.7 cells. That is, we showed that EA is a potent inhibitor of the production of nitric oxide and pro-inflammatory cytokines. The inhibitory activities of phenanthrenes were found to be caused by blockage of NF-kappa B activation and the phosphorylation of MAP kinases in the macrophages. These results are expected to serve as a guide for future studies on the ability of phenanthrenes to inhibit acute and chronic inflammatory diseases.en_US
dc.description.sponsorshipThis work was supported by the research Grant of the Chungbuk National University in 2013.en_US
dc.language.isoen_USen_US
dc.publisherPHARMACEUTICAL SOC KOREAen_US
dc.subjectInflammation;en_US
dc.subjectDendrobium nobileen_US
dc.subjectPhenanthrenesen_US
dc.subjectMacrophagesen_US
dc.subjectEphemeranthol Aen_US
dc.titleAnti-inflammatory effects of Dendrobium nobile derived phenanthrenes in LPS-stimulated murine macrophagesen_US
dc.typeArticleen_US
dc.relation.no6-
dc.relation.volume38-
dc.identifier.doi10.1007/s12272-014-0511-5-
dc.relation.page1117-1126-
dc.relation.journalARCHIVES OF PHARMACAL RESEARCH-
dc.contributor.googleauthorKim, JH-
dc.contributor.googleauthorOh, SY-
dc.contributor.googleauthorHan, SB-
dc.contributor.googleauthorUddin, GM-
dc.contributor.googleauthorKim, CY-
dc.contributor.googleauthorLee, JK-
dc.relation.code2015009399-
dc.sector.campusE-
dc.sector.daehakCOLLEGE OF PHARMACY[E]-
dc.sector.departmentDEPARTMENT OF PHARMACY-
dc.identifier.pidchulykim-
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COLLEGE OF PHARMACY[E](약학대학) > PHARMACY(약학과) > Articles
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