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dc.contributor.author이창화-
dc.date.accessioned2017-12-12T00:48:14Z-
dc.date.available2017-12-12T00:48:14Z-
dc.date.issued2016-02-
dc.identifier.citationARTIFICIAL ORGANS, v. 40, NO 2, Page. 136-143en_US
dc.identifier.issn0160-564X-
dc.identifier.issn1525-1594-
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/aor.12519/abstract;jsessionid=71ADD970FDC7609A75D5BAA8F0E8BDDE.f02t03-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/34074-
dc.description.abstractHyperuricemia following kidney transplantation (KT) may contribute to a decline in allograft renal function, but be affected by KT-related confounding factors. Some studies have even suggested that a reduction in serum uric acid (UA) is associated with poor patient outcomes. Thus, we retrospectively analyzed the impact of serum UA on allograft outcomes in 281 KT recipients. KT recipients were divided into five groups according to serum UA level (mg/dL): Group I (n = 46), = 5; Group II (n = 62), > 5 and = 6; Group III (n = 70), > 6 and = 7; Group IV (n = 53), > 7 and = 8; Group V (n = 50), > 8. Regression analysis showed that serumUAlevel was significantly associated with future allograft function. In a Kaplan-Meier analysis, the dialysis-free survival of Group II recipients was better than that of the other groups (Group I, 140 +/- 5 months; Group II, 208 +/- 7 months; Group III, 148 +/- 4 months; Group IV, 185 +/- 12 months; Group V, 164 +/- 11 months; P = 0.0164). In Cox proportional hazard models adjusting for estimated glomerular filtration rate, the relative risk of allograft loss still tended to be elevated in Group I (HR=3.417, 95% CI 1.138-10.258) and Group V (HR= 2.793, 95% CI 1.108-7.041), using Group II as the reference. Our results suggest that there is a J-shaped association between serum UA levels and allograft outcomes in living donor KT recipients.en_US
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELLen_US
dc.subjectGraft survivalen_US
dc.subjectKidneyen_US
dc.subjectTransplantationen_US
dc.subjectUric aciden_US
dc.titleA J-Shaped Association Between Serum Uric Acid Level and Allograft Outcomes After Living Donor Kidney Transplantationen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume40-
dc.identifier.doi10.1111/aor.12519-
dc.relation.page136-143-
dc.relation.journalARTIFICIAL ORGANS-
dc.contributor.googleauthorOh, Il Hwan-
dc.contributor.googleauthorKim, Jeong Eun-
dc.contributor.googleauthorLee, Chang Hwa-
dc.contributor.googleauthorKim, Gheun-Ho-
dc.contributor.googleauthorPark, Joon-Sung-
dc.relation.code2016000181-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidchanghwa-
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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