128 0

유방암세포에서 Phytosphingosine의 EGF 수용체 저해를 통한 상피간엽이행 조절

Title
유방암세포에서 Phytosphingosine의 EGF 수용체 저해를 통한 상피간엽이행 조절
Other Titles
Anti-EMT function of Phytosphingosine through downregulation of EGF receptor tyrosine kinase in breast cancer
Author
손한선
Alternative Author(s)
Son, Han Sun
Advisor(s)
이수재
Issue Date
2017-08
Publisher
한양대학교
Degree
Master
Abstract
The lack of effective anti-metastatic drugs for the eradication of breast cancer stem cells within tumors, which are often resistant to chemotherapy and radiotherapy, creates a major obstacle during metastatic breast cancer therapy. Even though D-ribophytosphingosine (PHS) is well known to activate protein kinase (MAPK)-mediated apoptosis, its possible role towards the metastasis signaling mechanisms underlying the epithelial-mesenchymal transition (EMT) remains largely unknown. In this report, I first time investigated the anti-metastatic potential of the natural sphingolipid PHS for the targeting of breast cancer cells as well as breast stem-like cells in vitro. The PHS-mediated inhibition of EMT was validated by changes in several EMT marker and regulators. It was found that PHS-based inhibition of EMT was attributable by the downregulation of the EGFR/JAK1/STAT3 signaling axis, as validated by immunoprecipitation assays and breast tumorigenesis mice models. Together, these findings strongly uncover a mechanism that PHS inhibits the metastatic ability of breast cancer by blocking EGFR phosphorylation and its downstream signaling node, providing a rationale for breast cancer therapies during tumor relapse.
URI
http://dcollection.hanyang.ac.kr/jsp/common/DcLoOrgPer.jsp?sItemId=000000103009http://hdl.handle.net/20.500.11754/33402
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > LIFE SCIENCE(생명과학과) > Theses (Ph.D.)
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE