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Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer

Title
Glutamate E15 and E171 are Hotspots in p60TRP-Related Cancer
Author
Heese, Klaus
Keywords
Ras; Cancer; GPRASP; p60TRP; Ran; BHLHB9; GASP
Issue Date
2016-02
Publisher
TAYLOR & FRANCIS INC
Citation
CANCER INVESTIGATION, v. 34, NO 2, Page. 64-69
Abstract
RAS protein is a small G protein linked to multiple G protein-coupled receptor (GPCR) signaling cascades and is responsible for various types of cancer, but to this day, Ras is considered "undruggable." Multiple alternative regulators of G protein signaling (RGS) pathways have become the focus of ongoing efforts to identify new cancer therapeutics. We analyzed human cancer genome datasets and describe p60TRP, a recently identified GPCR-associated sorting protein (GPRASP), and its role in various types of cancer. We found that some regions of p60TRP were more prone to specific mutations, with two hotspots for mutations at E15 and E171.
URI
http://www.tandfonline.com/doi/full/10.3109/07357907.2015.1088949http://hdl.handle.net/20.500.11754/31901
ISSN
0735-7907; 1532-4192
DOI
10.3109/07357907.2015.1088949
Appears in Collections:
GRADUATE SCHOOL OF BIOMEDICAL SCIENCE AND ENGINEERING[S](의생명공학전문대학원) > ETC
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