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dc.contributor.author최찬범-
dc.date.accessioned2017-11-24T02:24:09Z-
dc.date.available2017-11-24T02:24:09Z-
dc.date.issued2016-02-
dc.identifier.citationPLOS ONE, v. 11, NO 2, Article number e0150283, Page. 283-289en_US
dc.identifier.issn1932-6203-
dc.identifier.urihttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150283-
dc.identifier.urihttp://hdl.handle.net/20.500.11754/31833-
dc.description.abstractThe genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE.en_US
dc.description.sponsorshipThis study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1C1A1A02036527 to Dr. Kwangwoo Kim), the US National Institutes of Health (R01MD007909 and R01AR060366 to Dr. Swapan K. Nath), and the Korea Healthcare Technology R&D Project of the Ministry for Health & Welfare (HI13C2124 to Dr. Sang-Cheol Bae). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_US
dc.language.isoenen_US
dc.publisherPUBLIC LIBRARY SCIENCEen_US
dc.subjectEXPRESSIONen_US
dc.subjectMHCen_US
dc.subjectHLA-DR-BETA-1en_US
dc.subjectINDIVIDUALSen_US
dc.subjectHAPLOTYPEen_US
dc.subjectMOLECULESen_US
dc.subjectEXPLAINen_US
dc.titleImputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosusen_US
dc.typeArticleen_US
dc.relation.no2-
dc.relation.volume11-
dc.identifier.doi10.1371/journal.pone.0150283-
dc.relation.page283-289-
dc.relation.journalPLOS ONE-
dc.contributor.googleauthorKim, Kwangwoo-
dc.contributor.googleauthorBang, So-Young-
dc.contributor.googleauthorYoo, Dae Hyun-
dc.contributor.googleauthorCho, Soo-Kyung-
dc.contributor.googleauthorChoi, Chan-Bum-
dc.contributor.googleauthorSung, Yoon-Kyoung-
dc.contributor.googleauthorKim, Tae-Hwan-
dc.contributor.googleauthorJun, Jae-Bum-
dc.contributor.googleauthorKang, Young Mo-
dc.contributor.googleauthorSuh, Chang-Hee-
dc.relation.code2016007072-
dc.sector.campusS-
dc.sector.daehakCOLLEGE OF MEDICINE[S]-
dc.sector.departmentDEPARTMENT OF MEDICINE-
dc.identifier.pidcbchoi-
dc.identifier.researcherIDM-4110-2017-
dc.identifier.orcidhttp://orcid.org/0000-0002-4691-5455-


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