Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜순 | - |
dc.date.accessioned | 2017-11-24T02:16:16Z | - |
dc.date.available | 2017-11-24T02:16:16Z | - |
dc.date.issued | 2016-02 | - |
dc.identifier.citation | PLOS ONE, v. 11, NO 2, Article number e0150283, Page. 1-7 | en_US |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0150283 | - |
dc.identifier.uri | http://hdl.handle.net/20.500.11754/31832 | - |
dc.description.abstract | The genetic association of HLA-DRB1 with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) is well documented, but association with other HLA-DR beta genes (HLA-DRB3, HLA-DRB4 and HLA-DRB5) has not been thoroughly studied, despite their similar functions and chromosomal positions. We examined variants in all functional HLA-DR beta genes in RA and SLE patients and controls, down to the amino-acid level, to better understand disease association with the HLA-DR locus. To this end, we improved an existing HLA reference panel to impute variants in all protein-coding HLA-DR beta genes. Using the reference panel, HLA variants were inferred from high-density SNP data of 9,271 RA-control subjects and 5,342 SLE-control subjects. Disease association tests were performed by logistic regression and log-likelihood ratio tests. After imputation using the newly constructed HLA reference panel and statistical analysis, we observed that HLA-DRB1 variants better accounted for the association between MHC and susceptibility to RA and SLE than did the other three HLA-DRB variants. Moreover, there were no secondary effects in HLA-DRB3, HLA-DRB4, or HLA-DRB5 in RA or SLE. Of all the HLA-DR beta chain paralogs, those encoded by HLA-DRB1 solely or dominantly influence susceptibility to RA and SLE. | en_US |
dc.description.sponsorship | This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2015R1C1A1A02036527 to Dr. Kwangwoo Kim), the US National Institutes of Health (R01MD007909 and R01AR060366 to Dr. Swapan K. Nath), and the Korea Healthcare Technology R&D Project of the Ministry for Health & Welfare (HI13C2124 to Dr. Sang-Cheol Bae). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en_US |
dc.language.iso | en | en_US |
dc.publisher | PUBLIC LIBRARY SCIENCE | en_US |
dc.subject | EXPRESSION | en_US |
dc.subject | MHC | en_US |
dc.subject | HLA-DR-BETA-1 | en_US |
dc.subject | INDIVIDUALS | en_US |
dc.subject | HAPLOTYPE | en_US |
dc.subject | MOLECULES | en_US |
dc.subject | EXPLAIN | en_US |
dc.title | Imputing Variants in HLA-DR Beta Genes Reveals That HLA-DRB1 Is Solely Associated with Rheumatoid Arthritis and Systemic Lupus Erythematosus | en_US |
dc.type | Article | en_US |
dc.relation.no | 2 | - |
dc.relation.volume | 11 | - |
dc.identifier.doi | 10.1371/journal.pone.0150283 | - |
dc.relation.page | 1-7 | - |
dc.relation.journal | PLOS ONE | - |
dc.contributor.googleauthor | Kim, Kwangwoo | - |
dc.contributor.googleauthor | Bang, So-Young | - |
dc.contributor.googleauthor | Yoo, Dae Hyun | - |
dc.contributor.googleauthor | Cho, Soo-Kyung | - |
dc.contributor.googleauthor | Choi, Chan-Bum | - |
dc.contributor.googleauthor | Sung, Yoon-Kyoung | - |
dc.contributor.googleauthor | Kim, Tae-Hwan | - |
dc.contributor.googleauthor | Jun, Jae-Bum | - |
dc.contributor.googleauthor | Kang, Young Mo | - |
dc.contributor.googleauthor | Lee, Hye-Soon | - |
dc.relation.code | 2016007072 | - |
dc.sector.campus | S | - |
dc.sector.daehak | COLLEGE OF MEDICINE[S] | - |
dc.sector.department | DEPARTMENT OF MEDICINE | - |
dc.identifier.pid | lhsberon | - |
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