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Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles

Title
Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
Author
최종훈
Keywords
Iron oxide nanoparticles; Mycophenolic acid; Immunosuppressive drug; Magnetic resonance imaging; Drug delivery
Issue Date
2016-02
Publisher
ELSEVIER SCIENCE BV
Citation
COLLOIDS AND SURFACES B-BIOINTERFACES, v. 142, Page. 290-296
Abstract
Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved.
URI
http://www.sciencedirect.com/science/article/pii/S0927776516300406?via%3Dihubhttp://hdl.handle.net/20.500.11754/31806
ISSN
0927-7765; 1873-4367
DOI
10.1016/j.colsurfb.2016.01.040
Appears in Collections:
GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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