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Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes

Title
Radiogenomic correlation in lung adenocarcinoma with epidermal growth factor receptor mutations: Imaging features and histological subtypes
Author
최요원
Keywords
Computed tomography (CT); Lung; Adenocarcinoma; Epidermal growth factor receptor (EGFR); Mutation
Issue Date
2016-01
Publisher
SPRINGER
Citation
EUROPEAN RADIOLOGY, v. 26, NO 10, Page. 3660-3668
Abstract
To correlate imaging features of resected lung adenocarcinoma with epidermal growth factor receptor (EGFR) mutation and the IASLC/ATS/ERS classification histological subtypes. In 250 consecutive patients with resected lung adenocarcinoma, EGFR mutation status was correlated with demographics, imaging features including ground-glass opacity (GGO) proportion and the IASLC/ATS/ERS classification histological subtypes. EGFR mutations were significantly more frequent in women (54.5 % vs. 38.1 %, p = 0.011) and in never-smokers (54.7 % vs. 35.3 %, p = 0.003). GGO proportion was significantly higher in tumours with EGFR mutation than in those without (30.3 +/- 33.8 % vs. 19.0 +/- 29.3 %, p = 0.005). EGFR mutation was significantly more frequent in tumours with GGO aeyen 50 % and tumours with any GGO (p = 0.026 and 0.008, respectively). Adenocarcinomas with exon 19 or 21 mutation showed significantly higher GGO proportion than that in EGFR wild-type tumours (p = 0.009 and 0.029, respectively). Absence of GGO was an independent predictor of negative EGFR mutation (odds ratio, 1.81; 95 % confidence interval, 1.16-3.04; p = 0.018). GGO proportion in adenocarcinomas with EGFR mutation was significantly higher than that in EGFR wild-type tumours, and the absence of GGO on CT was an independent predictor of negative EGFR mutation. aEuro cent Ground-glass opacity (GGO) proportion is significantly higher in EGFR-mutated adenocarcinomas aEuro cent Exon 19 or 21 mutated adenocarcinomas shows significantly higher GGO proportion aEuro cent GGO absence is an independent predictor of negative EGFR mutation in lung adenocarcinomas.
URI
https://link.springer.com/article/10.1007%2Fs00330-015-4196-zhttp://hdl.handle.net/20.500.11754/30471
ISSN
0938-7994; 1432-1084
DOI
10.1007/s00330-015-4196-z
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COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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