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Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference

Title
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference
Author
최보율
Keywords
BODY-MASS INDEX; ANTHROPOMETRIC TRAITS; SEXUAL-DIMORPHISM; FAT DISTRIBUTION; METAANALYSIS; INSIGHTS; BIOLOGY; OBESITY; LINK
Issue Date
2016-01
Publisher
NATURE PUBLISHING GROUP
Citation
SCIENTIFIC REPORTS, v. 6, Article number 17958, Page. 6-10
Abstract
Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in Europeanancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3, CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.
URI
https://www.nature.com/articles/srep17958http://hdl.handle.net/20.500.11754/30445
ISSN
2045-2322
DOI
10.1038/srep17958
Appears in Collections:
COLLEGE OF MEDICINE[S](의과대학) > MEDICINE(의학과) > Articles
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