Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
- Title
- Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles
- Author
- Hong, Jong Wook
- Keywords
- Iron oxide nanoparticles; Mycophenolic acid; Immunosuppressive drug; Magnetic resonance imaging; Drug delivery
- Issue Date
- 2016-01
- Publisher
- ELSEVIER SCIENCE BV
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v. 142, Page. 290-296
- Abstract
- Iron oxide nanoparticles have been used in a wide range of biomedical applications, including drug delivery, molecular imaging, and cellular imaging. Various surface modifications have been applied to the particles to stabilize their surface and to give them a moiety for anchoring tags and/or drug molecules. Conventional methods of delivering immunosuppressant drugs often require a high dose of drugs to ensure therapeutic effects, but this can lead to toxic side effects. In this study, we used silica-coated iron oxide nanoparticles (IOSs) for a drug delivery application in which the nanoparticles carry the minimum amount of drug required to be effective to the target cells. IOSs could be loaded with water-insoluble immunosuppressive drug molecules (MPA: mycophenolic acid) and be used as a contrast agent for MRI. We characterized the IOSs for their physicochemical properties and found their average hydrodynamic diameter and core size to be 40.5 nm and 5 nm, respectively. Following the introduction of MPA-loaded IOSs (IOS/M), we evaluated the secretion dynamics of cytokines from peripheral blood mononuclear cells stimulated with phytohemagglutinin (PHA). The results showed that IOS/M effectively inhibited the secretion of the cytokines interleukin-2 and tumor necrosis factor a, with a minimal concentration of MPA. In conclusion, IOW may have potential applications in both efficient drug delivery and MRI. (C) 2016 Elsevier B.V. All rights reserved.
- URI
- http://www.sciencedirect.com/science/article/pii/S0927776516300406?via%3Dihubhttp://hdl.handle.net/20.500.11754/30443
- ISSN
- 0927-7765; 1873-4367
- DOI
- 10.1016/j.colsurfb.2016.01.040
- Appears in Collections:
- GRADUATE SCHOOL[S](대학원) > BIONANOTECHNOLOGY(바이오나노학과) > Articles
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