139 0

ECM1 regulates tumor metastasis and CSC-like property through stabilization of beta-catenin

Title
ECM1 regulates tumor metastasis and CSC-like property through stabilization of beta-catenin
Author
신인철
Keywords
EXTRACELLULAR-MATRIX PROTEIN-1; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; STEM-CELLS; LYMPHATIC METASTASIS; SIGNALING PATHWAYS; INITIATING CELLS; SELF-RENEWAL; EXPRESSION
Issue Date
2015-12
Publisher
NATURE PUBLISHING GROUP
Citation
ONCOGENE, v. 34, NO 50, Page. 6055-6065
Abstract
Extracellular Matrix Protein 1 (ECM1) is a marker for tumorigenesis and is correlated with invasiveness and poor prognosis in various types of cancer. However, the functional role of ECM1 in cancer metastasis is unclear. Here, we detected high ECM1 level in breast cancer patient sera that was associated with recurrence of tumor. The modulation of ECM1 expression affected not only cell migration and invasion, but also sphere-forming ability and drug resistance in breast cancer cell lines. In addition, ECM1 regulated the gene expression associated with the epithelial to mesenchymal transition (EMT) progression and cancer stem cell (CSC) maintenance. Interestingly, ECM1 increased beta-catenin expression at the post-translational level through induction of MUC1, which was physically associated with beta-catenin. Indeed, the association between beta-catenin and the MUC1 cytoplasmic tail was increased by ECM1. Furthermore, forced expression of beta-catenin altered the gene expression that potentiated EMT progression and CSC phenotype maintenance in the cells. These data provide evidence that ECM1 has an important role in cancer metastasis through beta-catenin stabilization.
URI
https://www.nature.com/onc/journal/v34/n50/full/onc201554a.htmlhttp://hdl.handle.net/20.500.11754/30180
ISSN
0950-9232; 1476-5594
DOI
10.1038/onc.2015.54
Appears in Collections:
COLLEGE OF NATURAL SCIENCES[S](자연과학대학) > LIFE SCIENCE(생명과학과) > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE